Synthesis, crystal structure and antibacterial activity of diaqua sulfato 2,4,6-tris(2-pyridyl)-s-triazine Zn(II) dihydrate

Abstract

In this study, zinc (II) complex [Zn(2,4,6-tris(2-pyridyl)-s-triazine)(OSO₃)(OH₂)₂]·2H₂O was synthesized using 2,4,6-tris(2-pyridyl)-s-triazine (TPTz) and ammonium pyrrolidine dithiocarbamate (NH₄PyDTC) as ligands. Surprisingly, the NH₄PyDTC ligand underwent dissociation and hydrolysis, resulting in the formation of sulfate ions. The synthesized Zn-complex was successfully characterized utilizing physical properties, magnetic susceptibility measurement, single-crystal X-ray diffraction, elemental analysis, ¹H-NMR, UV-Vis, and FT-IR spectroscopies. The X-ray analysis and several characterization techniques revealed that the Zn(II) complex was hexa-coordinated, associated with the tridentate TPTz ligand, two water molecules, and a mono-dentate sulfate ion. To assess the antibacterial effectiveness of the complex, it was tested on Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. The test result confirmed a significant antibacterial effect by inhibiting the growth of the bacteria more than the parent ligand. This research highlights the potential antibacterial effect of the sulfate-metal complex as a novel antibiotic development against both Gram-negative and Gram-positive bacteria.