Innovative approaches in atherosclerosis treatment: Harnessing traditional Chinese medicine to target long non-coding RNAs

IF 8.3 1区医学 Q1 CHEMISTRY, MEDICINAL Phytomedicine Pub Date : 2025-04-01 Epub Date: 2025-02-09 DOI:10.1016/j.phymed.2025.156488

Xiaofang Chen , Wenyan Ding , Yifan Liu , Hao Liu , Chi Zhang , Liang Huang

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Abstract

Background

Atherosclerosis (AS) is a major contributor to cardiovascular diseases, characterized by high morbidity and mortality rates. Long non-coding RNAs (LncRNAs), as members of non-protein coding RNAs, play a crucial role in various biological processes that maintain homeostasis and influence disease progression. Research indicates that lncRNAs are involved in the pathogenesis of AS.

Purpose

In this study, we aim to explore the role of lncRNAs in the pathogenesis of AS and the latest progress in the prevention and treatment of AS by targeted regulation of lncRNAs by traditional Chinese medicine (TCM), in order to provide more new beneficial targets for the treatment of AS and expand the application of TCM in the treatment of cardiovascular diseases.

Method

The literature was retrieved, analyzed, and collected using PubMed, Web of Science, Sci-Hub, CNKI, Elsevier, ScienceDirect, SpringerLink, and Google Scholar. Search terms include "atherosclerosis", "traditional Chinese medicine", "natural products", "active ingredient", "lncRNAs", "herbal medicine", "cardiovascular diseases", "pharmacology", "toxicology", "clinical trials", etc., and several combinations of these keywords.

Results

This study examines the primary mechanisms through which lncRNAs induce AS, such as dysfunction in endothelial cells, abnormal proliferation of vascular smooth muscle cells, cholesterol buildup in macrophages, formation of foam cells, inflammatory responses, and imbalances in lipid metabolism. Additionally, it summarizes 16 herbal monomers and 6 Chinese herbal compounds, along with an analysis of the toxicological aspects of TCM.

Conclusion

The study explores the existing approaches for modulating lncRNAs and emphasizes the significance and potential of herbal monomers, extracts, and formulations in this context.

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动脉粥样硬化治疗的创新途径：利用中药靶向长链非编码rna

背景：动脉粥样硬化（AS）是心血管疾病的主要致病因素，其特点是发病率和死亡率高。长链非编码rna （LncRNAs）作为非蛋白编码rna的成员，在维持体内平衡和影响疾病进展的各种生物过程中发挥着至关重要的作用。研究表明lncrna参与了AS的发病机制。目的本研究旨在探讨lncRNAs在AS发病机制中的作用，以及中医药靶向调控lncRNAs防治AS的最新进展，以期为AS的治疗提供更多新的有益靶点，扩大中医药在心血管疾病治疗中的应用。方法通过PubMed、Web of Science、Sci-Hub、CNKI、Elsevier、ScienceDirect、SpringerLink、谷歌Scholar等平台进行文献检索、分析和收集。搜索词包括“动脉粥样硬化”、“中药”、“天然产物”、“活性成分”、“lncRNAs”、“草药”、“心血管疾病”、“药理学”、“毒理学”、“临床试验”等，以及这些关键词的几种组合。本研究探讨了lncRNAs诱导AS的主要机制，如内皮细胞功能障碍、血管平滑肌细胞异常增殖、巨噬细胞胆固醇积聚、泡沫细胞形成、炎症反应和脂质代谢失衡。此外，总结了16种中药单体和6种中药化合物，并对中药的毒理学方面进行了分析。本研究探讨了现有的lncrna调控方法，并强调了草药单体、提取物和制剂在这方面的重要性和潜力。

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来源期刊

Phytomedicine 医学-药学

CiteScore

10.30

自引率

5.10%

发文量

670

审稿时长

91 days

期刊介绍： Phytomedicine is a therapy-oriented journal that publishes innovative studies on the efficacy, safety, quality, and mechanisms of action of specified plant extracts, phytopharmaceuticals, and their isolated constituents. This includes clinical, pharmacological, pharmacokinetic, and toxicological studies of herbal medicinal products, preparations, and purified compounds with defined and consistent quality, ensuring reproducible pharmacological activity. Founded in 1994, Phytomedicine aims to focus and stimulate research in this field and establish internationally accepted scientific standards for pharmacological studies, proof of clinical efficacy, and safety of phytomedicines.