Yellow light and ultrasound Dual-responsive strontium-doped zinc oxide composites for dental caries prevention and remineralization

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL Bioactive Materials Pub Date : 2025-02-12 DOI:10.1016/j.bioactmat.2025.01.029

Yujie Mu , Yanmei Wang , Lei Huang , Zhenzhen Weng , Tingting Zhong , Sisi Yu , Yiming Wen , Yingying Xu , Xiaolei Wang

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Abstract

Dental caries is one of the most prevalent chronic infectious diseases, mainly due to acid production by bacteria in the plaque biofilm, leading to enamel demineralization, tooth defects and pulpitis. Most of the current treatments are invasive and do not combine restoration of dental tissues, resolution of tooth staining or prevention of dental caries. In this study, a polydopamine (PDA)-encapsulated strontium-doped zinc oxide composite (Sr-ZnO@PDA, denoted as SZ@PDA) has been developed for caries prevention and remineralization. The PDA wrapping endows SZ@PDA with a narrow energy band gap (1.78 eV), which can simultaneously respond to yellow light (YL) with favorable biosafety and ultrasound (US) with high tissue penetration. The synergistic piezo-photocatalytic action of YL and US with the enhanced catalytic efficiency can generate an appropriate amount of reactive oxygen species (ROS), thus destroying the structure of bacterial cellular membranes and decomposing pigments for caries prevention and improvement of tooth staining, respectively. In addition, strontium ions (Sr²⁺) released by SZ@PDA, as an active element, can promote the remineralization of enamel and dentin, repairing defective dental tissues. Collectively, this versatile system (SZ@PDA) provides an effective strategy for the prevention and treatment of caries.

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.