{"title":"Solubilization of the New Generation Immunomodulator Fingolimod Using Natural, Modified, and Polymeric Cyclodextrins","authors":"A. A. Garibyan, E. S. Delyagina, I. V. Terekhova","doi":"10.1134/S0036024424703096","DOIUrl":null,"url":null,"abstract":"<p>Native, modified, and polymeric cyclodextrins are used for the first time to improve the solubility and bioavailability of synthetic immunomodulator fingolimod (FTY720). It is shown that the solubility of FTY720 grows in the presence of cyclodextrins. Constants of the stability of guest–host complexes and the index of efficiency of the solubilizing action of cyclodextrins are calculated from experimentally obtained phase solubility diagrams of FTY720. The effect the structure of cyclodextrin on the solubilization of FTY720 is considered.</p>","PeriodicalId":767,"journal":{"name":"Russian Journal of Physical Chemistry A","volume":"98 14","pages":"3504 - 3508"},"PeriodicalIF":0.7000,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Physical Chemistry A","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S0036024424703096","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Native, modified, and polymeric cyclodextrins are used for the first time to improve the solubility and bioavailability of synthetic immunomodulator fingolimod (FTY720). It is shown that the solubility of FTY720 grows in the presence of cyclodextrins. Constants of the stability of guest–host complexes and the index of efficiency of the solubilizing action of cyclodextrins are calculated from experimentally obtained phase solubility diagrams of FTY720. The effect the structure of cyclodextrin on the solubilization of FTY720 is considered.
期刊介绍：
Russian Journal of Physical Chemistry A. Focus on Chemistry (Zhurnal Fizicheskoi Khimii), founded in 1930, offers a comprehensive review of theoretical and experimental research from the Russian Academy of Sciences, leading research and academic centers from Russia and from all over the world.
Articles are devoted to chemical thermodynamics and thermochemistry, biophysical chemistry, photochemistry and magnetochemistry, materials structure, quantum chemistry, physical chemistry of nanomaterials and solutions, surface phenomena and adsorption, and methods and techniques of physicochemical studies.
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