{"title":"Ligand-Free Copper-Catalyzed N-Arylation of Pyrazolo[1,5-a]pyrimidin-7-Amines","authors":"Ting Pang, Tian Sang, Jing He, Ruili Guo, Jianwei Xie, Ping Liu","doi":"10.1002/aoc.70065","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>A simple and efficient approach was developed for ligand-free copper-promoted <i>N</i>-arylation of pyrazolo[1,5-<i>a</i>]pyrimidin-7-amines with aryliodides. A series of diarylamines and triarylamines could be obtained by controlling the reaction conditions. The reaction exhibited good functional-group tolerance, the feasibility of scale-up, and selectivity that make it particularly well suited for potential applications both in academic and industrial perspectives.</p>\n </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 3","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Organometallic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/aoc.70065","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
A simple and efficient approach was developed for ligand-free copper-promoted N-arylation of pyrazolo[1,5-a]pyrimidin-7-amines with aryliodides. A series of diarylamines and triarylamines could be obtained by controlling the reaction conditions. The reaction exhibited good functional-group tolerance, the feasibility of scale-up, and selectivity that make it particularly well suited for potential applications both in academic and industrial perspectives.
期刊介绍：
All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.
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