Remote cognitive tests predict neurodegenerative biomarkers in the Insight 46 cohort

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2025-02-12 DOI:10.1002/alz.14572

Martina Del Giovane, Valentina Giunchiglia, Ziyuan Cai, Marguerite Leoni, Rebecca Street, Kirsty Lu, Andrew Wong, Maria Popham, Jennifer M. Nicholas, William Trender, Peter J. Hellyer, Thomas D. Parker, Heidi Murray-Smith, David M. Cash, Josephine Barnes, Carole H. Sudre, Paresh A. Malhotra, Sebastian J. Crutch, Marcus Richards, Adam Hampshire, Jonathan M. Schott

{"title":"Remote cognitive tests predict neurodegenerative biomarkers in the Insight 46 cohort","authors":"Martina Del Giovane, Valentina Giunchiglia, Ziyuan Cai, Marguerite Leoni, Rebecca Street, Kirsty Lu, Andrew Wong, Maria Popham, Jennifer M. Nicholas, William Trender, Peter J. Hellyer, Thomas D. Parker, Heidi Murray-Smith, David M. Cash, Josephine Barnes, Carole H. Sudre, Paresh A. Malhotra, Sebastian J. Crutch, Marcus Richards, Adam Hampshire, Jonathan M. Schott","doi":"10.1002/alz.14572","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> BACKGROUND</h3>\n \n <p>Alzheimer's disease-related biomarkers detect pathology years before symptoms emerge, when disease-modifying therapies might be most beneficial. Remote cognitive testing provides a means of assessing early cognitive changes. We explored the relationship between neurodegenerative biomarkers and cognition in cognitively normal individuals.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>We remotely deployed 13 computerized Cognitron tasks in 255 Insight 46 participants. We generated amyloid load and positivity, white matter hyperintensity volume (WMHV), whole brain and hippocampal volumes at age 73, plus rates of change over 2 years. We examined the relationship between Cognitron, biomarkers, and standard neuropsychological tests.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Slower response time on a delayed recognition task predicted amyloid positivity (odds ratio [OR] = 1.79, confidence interval [CI]: 1.15, 2.95), and WMHV (1.23, CI: 1.00, 1.56). Brain and hippocampal atrophy rates correlated with poorer visuospatial performance (<i>b </i>= -0.42, CI: -0.80, -0.05) and accuracy on immediate recognition (<i>b </i>= -0.01, CI: -0.012, -0.001), respectively. Standard tests correlated with Cognitron composites (rho = 0.50, <i>p</i> < 0.001).</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>Remote computerized testing correlates with standard supervised assessments and holds potential for studying early cognitive changes associated with neurodegeneration.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>70% of the Online 46 cohort performed a set of remote online cognitive tasks.</li>\n \n <li>Response time and accuracy on a memory task predicted amyloid status and load (SUVR).</li>\n \n <li>Accuracy on memory and spatial span tasks correlated with longitudinal atrophy rate.</li>\n \n <li>The Cognitron tasks correlated with standard supervised cognitive tests.</li>\n \n <li>Online cognitive testing can help identify early AD-related memory deficits.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 2","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.14572","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14572","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

BACKGROUND

Alzheimer's disease-related biomarkers detect pathology years before symptoms emerge, when disease-modifying therapies might be most beneficial. Remote cognitive testing provides a means of assessing early cognitive changes. We explored the relationship between neurodegenerative biomarkers and cognition in cognitively normal individuals.

METHODS

We remotely deployed 13 computerized Cognitron tasks in 255 Insight 46 participants. We generated amyloid load and positivity, white matter hyperintensity volume (WMHV), whole brain and hippocampal volumes at age 73, plus rates of change over 2 years. We examined the relationship between Cognitron, biomarkers, and standard neuropsychological tests.

RESULTS

Slower response time on a delayed recognition task predicted amyloid positivity (odds ratio [OR] = 1.79, confidence interval [CI]: 1.15, 2.95), and WMHV (1.23, CI: 1.00, 1.56). Brain and hippocampal atrophy rates correlated with poorer visuospatial performance (b = -0.42, CI: -0.80, -0.05) and accuracy on immediate recognition (b = -0.01, CI: -0.012, -0.001), respectively. Standard tests correlated with Cognitron composites (rho = 0.50, p < 0.001).

DISCUSSION

Remote computerized testing correlates with standard supervised assessments and holds potential for studying early cognitive changes associated with neurodegeneration.

Highlights

70% of the Online 46 cohort performed a set of remote online cognitive tasks.
Response time and accuracy on a memory task predicted amyloid status and load (SUVR).
Accuracy on memory and spatial span tasks correlated with longitudinal atrophy rate.
The Cognitron tasks correlated with standard supervised cognitive tests.
Online cognitive testing can help identify early AD-related memory deficits.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

远程认知测试预测Insight 46队列中的神经退行性生物标志物

背景：阿尔茨海默病相关生物标志物在症状出现前几年检测病理，此时疾病修饰疗法可能是最有益的。远程认知测试提供了一种评估早期认知变化的方法。我们探讨了认知正常个体的神经退行性生物标志物与认知之间的关系。方法：我们在255名Insight 46参与者中远程部署了13个计算机化的Cognitron任务。我们测量了73岁时的淀粉样蛋白负荷和阳性、白质高强度体积（WMHV）、全脑和海马体积，以及2年内的变化率。我们检查了Cognitron、生物标志物和标准神经心理学测试之间的关系。结果延迟识别任务较慢的反应时间预测淀粉样蛋白阳性（优势比[OR] = 1.79，置信区间[CI]: 1.15, 2.95）和WMHV （1.23, CI: 1.00, 1.56）。脑和海马萎缩率分别与较差的视觉空间表现（b = -0.42, CI: -0.80, -0.05）和即时识别准确性（b = -0.01, CI: -0.012, -0.001）相关。标准测试与Cognitron复合材料相关(rho = 0.50, p <；0.001)。远程计算机化测试与标准监督评估相关，具有研究与神经变性相关的早期认知变化的潜力。70%的在线46队列执行了一组远程在线认知任务。记忆任务的反应时间和准确性预测淀粉样蛋白状态和负荷（SUVR）。记忆和空间跨度任务的准确性与纵向萎缩率相关。Cognitron任务与标准的监督认知测试相关。在线认知测试可以帮助识别早期ad相关的记忆缺陷。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.