{"title":"Cucurbit[7]uril encapsulation completely protects reactive imine in weak acid.","authors":"Kejia Shi, Bradley D Smith","doi":"10.1039/d4ob01879f","DOIUrl":null,"url":null,"abstract":"<p><p>An imine derived from 4-(<i>N</i>,<i>N</i>-dimethylamino)benzaldehyde and a primary amine undergoes very rapid hydrolysis in weak acid, however, it can be encapsulated within cucurbit[7]uril (CB7) to give a host/guest complex that completely protects the labile imine bond.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic & Biomolecular Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4ob01879f","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
An imine derived from 4-(N,N-dimethylamino)benzaldehyde and a primary amine undergoes very rapid hydrolysis in weak acid, however, it can be encapsulated within cucurbit[7]uril (CB7) to give a host/guest complex that completely protects the labile imine bond.
期刊介绍：
Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.
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