{"title":"Interplay of Retinal and Choroidal Vasculatures in Ocular Health and Disease.","authors":"Albert L Gonzales, Alexa Paikai, David Maeng","doi":"10.1007/978-3-031-76550-6_75","DOIUrl":null,"url":null,"abstract":"<p><p>The eye, a complex sensory organ, integrates the cornea, lens, and choroid to focus light onto retinal photoreceptor cells, converting light into electrical signals for visual interpretation. This intricate process is vital for human perception, enabling navigation, object recognition, and a rich visual experience. The circulatory system plays a crucial role in delivering nutrients, O<sub>2</sub>, and removing waste from cells, contributing to intraocular pressure regulation and maintaining eye structure. Photoreceptors, highly metabolically demanding cells, rely on retinal and choroidal vasculatures for O<sub>2</sub> and nutrients. This chapter emphasizes structural and functional distinctions between retinal and choroidal vasculature, exploring their implications in the pathophysiological development of diverse retinal degenerative diseases.</p>","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1468 ","pages":"459-463"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in experimental medicine and biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/978-3-031-76550-6_75","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
The eye, a complex sensory organ, integrates the cornea, lens, and choroid to focus light onto retinal photoreceptor cells, converting light into electrical signals for visual interpretation. This intricate process is vital for human perception, enabling navigation, object recognition, and a rich visual experience. The circulatory system plays a crucial role in delivering nutrients, O2, and removing waste from cells, contributing to intraocular pressure regulation and maintaining eye structure. Photoreceptors, highly metabolically demanding cells, rely on retinal and choroidal vasculatures for O2 and nutrients. This chapter emphasizes structural and functional distinctions between retinal and choroidal vasculature, exploring their implications in the pathophysiological development of diverse retinal degenerative diseases.
期刊介绍：
Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.
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