[The association of NOS1AP gene polymorphisms with the duration of the QT interval in patients with schizophrenia receiving antipsychotic therapy].

Abstract

Objective: To study the associations of NOS1AP gene polymorphisms with the duration of the QT interval (QTc) in patients with schizophrenia receiving antipsychotics.

Material and methods: One hundred and sixty-eight patients (78 men and 90 women) with an established diagnosis of schizophrenia were examined. The patients received basic antipsychotic therapy. At the time of admission to the hospital, a standard 12-lead electrocardiogram recording was performed. The calculation of the QTc interval was carried out using the Bazett formula. Three NOS1AP polymorphisms (rs12029454, rs10494366 and rs12143842) were selected for genotyping.

Results: Spearman's correlation revealed a significant relationship between CPZeq and the duration of the QTc interval in the group of men (r_s=0.262; p=0.021; p_Bonf=0.042). CPZeq was positively correlated with the duration of the QTc interval in men with AA and AG rs12029454 (r_s=0.717; p=0.00025; p_bonf=0.0015), GG and GT rs10494366 (r_s=0.381; p=0.008; p_bonf=0.048), TT and CT rs12143842 (r_s=0.389; p=0.003; p_bonf=0.018) genotypes. We did not find any significant correlations in the group of women.

Conclusion: Genetic variants rs12029454, rs10494366 and rs12143842 of the NOS1AP gene are associated with the duration of the QTc interval in men with schizophrenia in response to antipsychotics. The AA/AG rs12029454, GG/GT rs10494366 and TT/CT rs12143842 genotypes in men contribute to the prolongation of the QTc interval and the development of undesirable cardiovascular disorders against the background of antipsychotic therapy.