Cannabinoid spoilage, metabolism and cannabidiol(CBD) conversion to Tetrahydrocannabinol(THC) mechanisms with energetic parameters.

IF 4.1 Q1 PHARMACOLOGY & PHARMACY Journal of cannabis research Pub Date : 2025-02-10 DOI:10.1186/s42238-024-00239-7
Alwyn Henriques
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Abstract

Chemical redox mechanisms and thermodynamic parameters of the Cannabinoids Δ9-Tetrahydrocannabinol (THC) and cannabidiol (CBD) were determined theoretically and using activated complex theory then compared to physical experimentations of chemical spoilage by Pholsiri T et al. and intramolecular conversion of CBD to thc by Daniels. R. et al. Thermodynamic parameters were derived from activated complex theory using standard bond enthalpy data from the elments of Physical Chemistry by Atkins ((Atkins, Elements of Physical Chemistry, 2001)). Situations where psychotropic cannabinoids found in CBD based products were also understood due to the parameters that drive the reduction process of conversion to THC. The metabolism process of cannabinoids has been detailed from consumption to excretion with mechanistic support to deactivation and glucuronidation in order to have a cannabis standard established.

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大麻素的腐败、代谢和大麻二酚(CBD)转化为四氢大麻酚(THC)的机制与能量参数。
利用活化复合物理论从理论上确定了大麻素Δ9-四氢大麻酚(THC)和大麻二酚(CBD)的化学氧化还原机制和热力学参数,然后与 Pholsiri T 等人的化学腐败物理实验和 Daniels.热力学参数是利用阿特金斯所著《物理化学要素》(阿特金斯,《物理化学要素》,2001 年)中的标准键焓数据,通过活化复合物理论得出的。还了解了基于 CBD 的产品中发现的精神类大麻素的情况,因为这些参数推动了向四氢大麻酚转化的还原过程。大麻素的新陈代谢过程从食用到排泄都有详细说明,并对失活和葡萄糖醛酸化提供了机理支持,以便制定大麻标准。
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来源期刊
CiteScore
6.20
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0.00%
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