Ruthenium(II) complexes synthesized as potential inducers of conformation inversion of AS1411 G4 DNA

IF 3.2 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Inorganica Chimica Acta Pub Date : 2025-02-06 DOI:10.1016/j.ica.2025.122585

Peishan Huang , Wenhui Deng , Qiong Wu , Wanwan Hong , Jing Liu , Jiangbo Liang , Bin Zhao , Wenjie Mei

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Abstract

Herein, four ruthenium(II) complexes, [Ru(L)₂(PEIP)(CH₂)₄Br)](ClO₄)₂ (L = phen, 1; bpy, 2, PEIP = 2-(2-phenyl-ethenyl)-1H-imidazole-[4,5f][1,10]phenanthroline) and [Ru(L)₂(PEIP)(CH₂)₄Erianin)](ClO₄)₂ (L = phen, 1E; bpy, 2E) have been synthesized and investigated as promising inducer to promote conformation inversion of AS1411 G4 DNA. All of these complexes can bind and stabilize AS1411 G4 DNA. Subsequent investigations reveal that in the presence of 1 and 1E, the described circular dichroism signal of AS1411 G4 DNA was reversed. Furthermore, it is discovered that in the presence of 1 and 1E, AS1411 G4 DNA can condense to a somewhat loose nano-network. Moreover, the analysis using molecular docking demonstrates that the conformation inversion of AS1411 G4 DNA is largely dependent on the binding sites of 1 and 1E. In conclusion, these complexes will be used for tumor diagnostics in the clinical context because of their capacity to stably bind AS1411 G4 DNA and dramatically boost its fluorescence emission. Besides, these complexes show promise as inducers of AS1411 G4 DNA conformational inversion.

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作为 AS1411 G4 DNA 构象反转潜在诱导剂合成的钌（II）配合物

其中，钌（II）配合物[Ru(L)2(PEIP)(CH2)4Br)](ClO4)2 (L = phen, 1；bpy, 2, PEIP = 2-（2-苯基-乙烯基）- 1h -咪唑-[4,5f][1,10]菲罗啉)和[Ru(L)2(PEIP)(CH2)4Erianin)](ClO4)2 (L = phen, 1E；bpy, 2E)作为诱导as1411g4 DNA构象反转的有前景的诱导剂进行了研究。所有这些复合物都可以结合并稳定AS1411 G4 DNA。随后的研究表明，在1和1E的存在下，AS1411 G4 DNA的圆形二色性信号被逆转。此外，我们还发现，在1和1E的存在下，AS1411 G4 DNA可以凝聚成一个松散的纳米网络。此外，分子对接分析表明，AS1411 G4 DNA的构象反转很大程度上依赖于1和1E的结合位点。总之，由于这些复合物能够稳定结合AS1411 G4 DNA并显著增强其荧光发射，因此将在临床环境中用于肿瘤诊断。此外，这些复合物有望作为as1411g4 DNA构象反转的诱导剂。

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产品信息

阿拉丁

Erianin

阿拉丁

1,4-dibromobutane

来源期刊

Inorganica Chimica Acta 化学-无机化学与核化学

CiteScore

6.00

自引率

3.60%

发文量

440

审稿时长

35 days

期刊介绍： Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews. Topics covered include: • chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies; • synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs); • reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models; • applications of inorganic compounds, metallodrugs and molecule-based materials. Papers composed primarily of structural reports will typically not be considered for publication.

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