Ying Niu , Yan-Ling Liu , Yan-Gang Cao , Yi-Xin Zhao , Xu Chen , Di Lu , Bing-Xian Zhao , Xiao-Ke Zheng , Wei-Sheng Feng
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引用次数: 0
Abstract
Five undescribed glycosides (1–5) and eight known compounds (6–13) were isolated from the stems of Ephedra intermedia. Their chemical structures were determined by analysis of NMR, ECD, and MS data. In addition, The in vitro bioactive assay, α-glucosidase and acetylcholinesterase (AChE) inhibitory activities, suggested that compounds 11 and 12 exhibited obvious inhibitory effects on α-glucosidase with the IC50 value of 49.51 ± 0.97 μM and 47.12 ± 0.98 μM, respectively, compounds 4 and 5 showed weak inhibitory effects on AChE at the concentration of 100 μM.
期刊介绍：
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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