Research trends and hot spots in obesity-induced pain: A bibliometric analysis of the last 20 years

IF 2 Q3 NEUROSCIENCES IBRO Neuroscience Reports Pub Date : 2025-02-10 DOI:10.1016/j.ibneur.2025.02.001

Lei Gao , Yazhou Wen , Kunlin Guo, Renqi Li, Mao Mao, Shanwu Feng, Xian Wang

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Abstract

Background

Obesity can directly lead to allodynia, increase the incidence of chronic pain, and aggravate existing pain. However, the mechanisms underlying obesity-related or obesity-induced pain are still not understood. Herein, we performed a comprehensive bibliometric analysis of obesity-related or obesity-induced pain, aiming to analyze the current trends and hot spots as well as explore the underlying mechanisms.

Methods

We searched reviews and articles on obesity-related or obesity-induced pain from 2005 to 2024 via the Web of Science Core Collection (WoSCC) database. We subsequently conducted bibliometric analysis employing WPS Office, a web-based bibliometric analysis platform (https://bibliometric.com), VOSviewer, Pajek, and CiteSpace.

Results

In total, 347 papers were identified for bibliometric analysis. The country, institution, and journal with the greatest influence were the USA, Albert Einstein College of Medicine, and Headache, respectively. Dr. Lipton RB and Dr. Karppinen J were the top 2 influential authors on the basis of their significant number of publications and citations. The keywords for the latest burst were "inflammation," "risk," "neuropathic pain," "gene-related peptide," "knee osteoarthritis," and "validation." Notably, the article titled "The association between chronic obesity and pain" by Okifuji A received the highest number of citations as well as the strongest citation burst. He and colleagues noted a significant correlation between obesity and pain in terms of clinical manifestations, but this connection is indirect and is modulated by certain biomechanical and structural alterations linked to obesity, inflammatory agents, mood disorders, sleep disturbances, and lifestyles.

Conclusion

There has been a notable surge in the number of articles published in the last two decades. The investigation into neuroendocrine and neuroimmune mechanisms underlying obesity-related or obesity-induced pain is expected to be a hot spot in the coming years. A potential strategy for treating chronic obesity and pain should pay attention to particular endocrine regulators, inflammatory cytokines, or immune cells that serve as central elements or crucial signaling pathways within this regulatory system.

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