{"title":"Cover Feature: The Mysterious World of Non-Canonical Caps – What We Know and Why We Need New Sequencing Techniques (ChemBioChem 3/2025)","authors":"Flaminia Mancini, Hana Cahova","doi":"10.1002/cbic.202580304","DOIUrl":null,"url":null,"abstract":"<p>Dive into the intriguing world of 5’ non-canonical RNA caps —unique modifications derived from metabolites and cofactors such as NAD, FAD, CoA, UDP-glucose, UDP-N-acetylglucosamine, and dinucleoside polyphosphates—that challenge the long-held belief that RNA is capped solely by N7-methylguanosine. This review 10.1002/cbic.202400604 by Flaminia Mancini and Hana Cahova highlights how cutting-edge techniques like LC-MS have uncovered these caps across all domains of life and evaluates existing sequencing methods, emphasizing the urgent need for innovative technologies to decipher their biological roles. Discover a rapidly evolving field that could reshape our understanding of RNA biology.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure>\n </p>","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":"26 3","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cbic.202580304","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemBioChem","FirstCategoryId":"99","ListUrlMain":"https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202580304","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
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Abstract
Dive into the intriguing world of 5’ non-canonical RNA caps —unique modifications derived from metabolites and cofactors such as NAD, FAD, CoA, UDP-glucose, UDP-N-acetylglucosamine, and dinucleoside polyphosphates—that challenge the long-held belief that RNA is capped solely by N7-methylguanosine. This review 10.1002/cbic.202400604 by Flaminia Mancini and Hana Cahova highlights how cutting-edge techniques like LC-MS have uncovered these caps across all domains of life and evaluates existing sequencing methods, emphasizing the urgent need for innovative technologies to decipher their biological roles. Discover a rapidly evolving field that could reshape our understanding of RNA biology.
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ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).
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