Temporal Trends and Demographic Insights Into Mortality From Systemic Lupus Erythematosus, 1999–2020

IF 3.3 2区医学 Q1 RHEUMATOLOGY Arthritis Care & Research Pub Date : 2025-02-12 DOI:10.1002/acr.25509

Ansaam Daoud, Loai Dweik, Omer Pamuk

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Abstract

Objective

Previous studies showed a decline in systemic lupus erythematosus (SLE) mortality rates from 1968 to 2013, yet mortality rates remained high relative to non-SLE mortality rates, with notable disparities. We aimed to delineate demographic characteristics associated with SLE deaths and map out the national and geographic trends of the last two decades.

Methods

We analyzed SLE deaths data from 1999 to 2020 using the Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research Multiple Cause of Death database. Age-adjusted mortality rates (AAMRs) were computed based on sex, race and ethnicity, and state. Trends over the study period were evaluated using a simple linear regression model.

Results

From 1999 to 2020, we identified 27,213 deaths with SLE as the underlying cause in the United States. Female participants experienced a higher AAMR (6.21 per million, 95% confidence interval [95% CI] 6.13–6.29) than male participants (1.20 per million, 95% CI 1.16–1.24). African American participants had the highest AAMR (10.7 per million, 95% CI 10.48–10.92), particularly among female participants (17.68 per million, 95% CI 17.29–18.06). Linear regression analysis found a significant decline in the SLE AAMR from 1999 to 2020 (R² = 0.902), with decreases noticed across all demographic groups. The SLE AAMR to the non-SLE AAMR ratio showed a sustained decline from 2005 to 2020 (R² = 0.8552). Analysis of the geographic distribution of SLE AAMR in the United States reveals a pronounced concentration in Southern states.

Conclusion

Since 1999, SLE-related mortality rates have consistently declined across various demographic groups, though rates remain disproportionately high in African American participants, particularly among African American female participants and in Southern states.

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1999-2020年系统性红斑狼疮死亡率的时间趋势和人口统计学见解。

目的：既往研究显示1968 - 2013年系统性红斑狼疮（SLE）死亡率有所下降，但与非SLE死亡率相比，SLE死亡率仍然较高，且差异显著。我们的目的是描述与SLE死亡率相关的人口统计学特征，并绘制出过去20年的国家和地理趋势。方法：我们使用疾病控制和预防中心广泛的流行病学研究多死因在线数据数据库分析1999年至2020年的SLE死亡率数据。年龄调整死亡率（AAMRs）是根据性别、种族和民族以及州来计算的。使用简单的线性回归模型评估研究期间的趋势。结果：从1999年到2020年，我们在美国确定了27,213例SLE死亡作为潜在原因。女性的AAMR（6.21/百万，95%CI: 6.13-6.29）高于男性（1.20/百万，95%CI: 1.16-1.24）。非裔美国人（AA）的AAMR最高（10.7/百万人，95%CI: 10.48-10.92），尤其是女性（17.68/百万人，95%CI: 17.29-18.06）。线性回归分析发现，从1999年到2020年，SLE AAMR显著下降（R2=0.902），所有人口统计群体都注意到下降。SLE AAMR与非SLE AAMR之比从2005年到2020年呈持续下降趋势（R2 =0.8552）。分析SLE AAMR在美国的地理分布，发现南部各州明显集中。结论：自1999年以来，在不同的人口群体中，与精神分裂症相关的死亡率一直在下降，尽管在AA群体中，特别是在AA女性群体和南部各州，死亡率仍然高得不成比例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arthritis Care & Research RHEUMATOLOGY-

CiteScore

9.40

自引率

6.40%

发文量

368

审稿时长

3-6 weeks

期刊介绍： Arthritis Care & Research, an official journal of the American College of Rheumatology and the Association of Rheumatology Health Professionals (a division of the College), is a peer-reviewed publication that publishes original research, review articles, and editorials that promote excellence in the clinical practice of rheumatology. Relevant to the care of individuals with rheumatic diseases, major topics are evidence-based practice studies, clinical problems, practice guidelines, educational, social, and public health issues, health economics, health care policy, and future trends in rheumatology practice.