Cumulative Incidence of Mortality Associated with Cardiovascular-Kidney-Metabolic (CKM) Syndrome.

IF 9.4 1区医学 Q1 UROLOGY & NEPHROLOGY Journal of The American Society of Nephrology Pub Date : 2025-02-11 DOI:10.1681/ASN.0000000637

Sophie E Claudel, Insa M Schmidt, Sushrut S Waikar, Ashish Verma

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与心血管-肾-代谢综合征相关的累积死亡率

背景：批判性地评估心血管-肾-代谢（CKM）综合征分期对临床实践的预后影响是必要的。本文的主要目的是确定与CKM综合征各阶段相关的死亡风险，并确定相应的15年限制平均生存时间。方法：这是一项对50,678名20岁及以上的美国社区居民进行的纵向研究，他们参加了1999-2018年全国健康与营养检查调查，并获得了CKM分期的基线数据。CKM分期是根据美国心脏协会主席的建议确定的。根据混杂因素调整后的生存曲线，使用g公式计算每个阶段经过15年调整的心血管死亡率累积发生率。结果：在中位9.5年的随访中，2564名参与者经历了心血管死亡。经15年校正的心血管死亡率累积发生率为：0期，5.5% (95% CI, 1.8-9.3)；第一阶段，5.7% (95% CI, 3.2-8.2)；第二阶段，7.9% (95% CI, 6.8-9.1)；第三阶段，8.7% (95% CI 6.7-10.8)；第四阶段，15.2% （95% CI, 13.6-16.8）。15年时，CKM 4期和0期的绝对风险差为9.6% （95% CI, 5.6-13.6）。CKM 0期和4期在15年时的生存差为5.6 （95% CI, 5.5-5.7个月）。结论：我们的研究结果显示，CKM综合征分期越高，心血管死亡风险越高。

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来源期刊

Journal of The American Society of Nephrology 医学-泌尿学与肾脏学

CiteScore

22.40

自引率

2.90%

发文量

492

审稿时长

3-8 weeks

期刊介绍： The Journal of the American Society of Nephrology (JASN) stands as the preeminent kidney journal globally, offering an exceptional synthesis of cutting-edge basic research, clinical epidemiology, meta-analysis, and relevant editorial content. Representing a comprehensive resource, JASN encompasses clinical research, editorials distilling key findings, perspectives, and timely reviews. Editorials are skillfully crafted to elucidate the essential insights of the parent article, while JASN actively encourages the submission of Letters to the Editor discussing recently published articles. The reviews featured in JASN are consistently erudite and comprehensive, providing thorough coverage of respective fields. Since its inception in July 1990, JASN has been a monthly publication. JASN publishes original research reports and editorial content across a spectrum of basic and clinical science relevant to the broad discipline of nephrology. Topics covered include renal cell biology, developmental biology of the kidney, genetics of kidney disease, cell and transport physiology, hemodynamics and vascular regulation, mechanisms of blood pressure regulation, renal immunology, kidney pathology, pathophysiology of kidney diseases, nephrolithiasis, clinical nephrology (including dialysis and transplantation), and hypertension. Furthermore, articles addressing healthcare policy and care delivery issues relevant to nephrology are warmly welcomed.