Effect of Aspirin on Biomarkers of Barrett's Esophagus After Successful Eradication with Radiofrequency Ablation.

IF 2.5 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Digestive Diseases and Sciences Pub Date : 2025-03-01 Epub Date: 2025-02-11 DOI:10.1007/s10620-025-08908-0

Robert S Bresalier, Nicholas J Shaheen, Mike Hernandez, Navtej Buttar, Norman Marcon, Sachin Wani, Raman Muthusamy, Gary Falk, Tamara Tipps Johnson, Peiying Yan, Xiaofang Huo, Tawana A Castille, Gary Della'Zanna, Ellen Richmond, J Jack Lee, Powel Brown, Rhonda Souza

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引用次数: 0

Abstract

Objectives/methods: Placebo-controlled phase II study evaluated aspirin's effect on CDX2 mRNA and prostanoid production in native and neosquamous epithelium after successful radiofrequency ablation (RFA) in Barrett's esophagus.

Results: At 12 months TXB2, PGF2α, PGD2, PGE2, PGE1, and α13PGE2 increased in native squamous but not neosquamous epithelium in individuals randomized to placebo. Aspirin use significantly reduced CDX2 mRNA in native squamous epithelium, and was associated with decreases in PGE1, PGE2 and 13PGE2 in neosquamous epithelium.

Conclusions: After RFA, native squamous and neosquamous epithelium exhibit different molecular markers and responses to aspirin suggesting that different sources of squamous progenitors contribute to esophageal re-epithelization.

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阿司匹林对射频消融术成功根除巴雷特食管生物标志物的影响。

目的/方法：安慰剂对照II期研究评估阿司匹林对Barrett食管射频消融（RFA）成功后原生和新鳞状上皮CDX2 mRNA和前列腺素生成的影响。结果：在12个月时，随机分配到安慰剂组的个体的TXB2、PGF2α、PGD2、PGE2、PGE1和α13PGE2在原生鳞状上皮中增加，而在新鳞状上皮中没有增加。阿司匹林可显著降低天然鳞状上皮中CDX2 mRNA的表达，并与新鳞状上皮中PGE1、PGE2和13PGE2的表达降低相关。结论：RFA后，原生鳞状上皮和新鳞状上皮表现出不同的分子标记和对阿司匹林的反应，表明不同来源的鳞状上皮祖细胞有助于食管再上皮形成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Digestive Diseases and Sciences 医学-胃肠肝病学

CiteScore

6.40

自引率

3.20%

发文量

420

审稿时长

1 months

期刊介绍： Digestive Diseases and Sciences publishes high-quality, peer-reviewed, original papers addressing aspects of basic/translational and clinical research in gastroenterology, hepatology, and related fields. This well-illustrated journal features comprehensive coverage of basic pathophysiology, new technological advances, and clinical breakthroughs; insights from prominent academicians and practitioners concerning new scientific developments and practical medical issues; and discussions focusing on the latest changes in local and worldwide social, economic, and governmental policies that affect the delivery of care within the disciplines of gastroenterology and hepatology.