Mendelian randomization analysis reveals causal relationship between tonsillectomy and irritable bowel syndrome.

IF 1.6 4区医学 Q2 SURGERY Frontiers in Surgery Pub Date : 2025-01-28 eCollection Date: 2025-01-01 DOI:10.3389/fsurg.2025.1436227

Huaiquan Liu, Shuoshuo Shao, Bo Chen, Shili Yang, Xinyan Zhang

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Abstract

Objective: This study used two sample Mendelian randomization (MR) method to evaluate the causal relationship between tonsillectomy and irritable bowel syndrome (IBS).

Methods: We selected tonsillectomy as the exposure factor and IBS as the outcome variable, using GWAS data from the IEU Open GWAS project. Instrumental variables (IVs) were SNPs strongly correlated and independent of tonsillectomy. MR-PRESSO was used for outlier removal. IVW was the primary MR analysis method, supplemented by MR-Egger regression, WM, WME, and simple mode. Cochran's Q tests assessed heterogeneity. MR-Egger intercept tested horizontal pleiotropy. Sensitivity analysis used a leave-one-out method.

Results: The IVW analysis indicated a positive association between genetically predicted tonsillectomy and IBS (OR = 1.682, 95% CI: 1.157-2.446, P = 0.006). Heterogeneity tests revealed the presence of heterogeneity at the SNPs (Cochran Q test, P = 3.13 × 10^-5. The MR-Egger intercept test did not detect horizontal pleiotropy (egger_intercept = 0.000914, P = 0.789). Sensitivity analysis demonstrated the stability of the results. All F-statistics were greater than 10, indicating the absence of weak instrument bias.

Conclusion: Genetics predicts a positive causal relationship between tonsillectomy and IBS, suggesting that prevention of IBS in tonsillectomy patients should be enhanced.

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孟德尔随机分析揭示扁桃体切除术与肠易激综合征之间的因果关系。

目的：本研究采用双样本孟德尔随机化（MR）方法评价扁桃体切除术与肠易激综合征（IBS）的因果关系。方法：我们选择扁桃体切除术作为暴露因素，IBS作为结果变量，使用IEU Open GWAS项目的GWAS数据。工具变量（IVs）是与扁桃体切除术高度相关且独立的snp。MR-PRESSO用于异常值去除。以IVW为主要MR分析方法，其次为MR- egger回归、WM、WME和简单模型。科克伦Q测试评估异质性。MR-Egger截距测试水平多效性。敏感性分析采用留一法。结果：IVW分析显示遗传预测扁桃体切除术与IBS呈正相关（OR = 1.682, 95% CI: 1.157-2.446, P = 0.006）。异质性检验显示snp存在异质性（Cochran Q检验，P = 3.13 × 10-5）。MR-Egger截距检验未检测到水平多效性（egger_intercept = 0.000914, P = 0.789）。敏感性分析证明了结果的稳定性。所有f统计量均大于10，表明不存在弱工具偏倚。结论：遗传学预测扁桃体切除术与肠易激综合征之间存在正相关关系，提示扁桃体切除术患者应加强对肠易激综合征的预防。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Surgery Medicine-Surgery

CiteScore

1.90

自引率

11.10%

发文量

1872

审稿时长

12 weeks

期刊介绍： Evidence of surgical interventions go back to prehistoric times. Since then, the field of surgery has developed into a complex array of specialties and procedures, particularly with the advent of microsurgery, lasers and minimally invasive techniques. The advanced skills now required from surgeons has led to ever increasing specialization, though these still share important fundamental principles. Frontiers in Surgery is the umbrella journal representing the publication interests of all surgical specialties. It is divided into several “Specialty Sections” listed below. All these sections have their own Specialty Chief Editor, Editorial Board and homepage, but all articles carry the citation Frontiers in Surgery. Frontiers in Surgery calls upon medical professionals and scientists from all surgical specialties to publish their experimental and clinical studies in this journal. By assembling all surgical specialties, which nonetheless retain their independence, under the common umbrella of Frontiers in Surgery, a powerful publication venue is created. Since there is often overlap and common ground between the different surgical specialties, assembly of all surgical disciplines into a single journal will foster a collaborative dialogue amongst the surgical community. This means that publications, which are also of interest to other surgical specialties, will reach a wider audience and have greater impact. The aim of this multidisciplinary journal is to create a discussion and knowledge platform of advances and research findings in surgical practice today to continuously improve clinical management of patients and foster innovation in this field.