A Study of Body Composition in Children Suffering From Infantile Vitamin B12 Deficiency

IF 1.4 4区医学 Q2 PEDIATRICS Journal of paediatrics and child health Pub Date : 2025-02-11 DOI:10.1111/jpc.70000

Viresh Vohra, Harvinder Kaur, Savita Verma Attri, Bhavneet Bharati, Pawan Kumar, Shivan Kesavan, Naveen Sankhyan

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Abstract

Background

Infantile tremor syndrome (ITS), or neurocutaneous infantile vitamin B12 deficiency syndrome (NIBS), is characterised by tremors, developmental delay, anaemia and skin hyperpigmentation. This study aimed to assess the body composition and serum lipids in children with ITS.

Methods

Children under 2 years of age with a clinical diagnosis of ITS were enrolled. Dietary history, developmental milestones and anthropometric data were recorded, along with blood tests for B12, homocysteine, lipid profile and blood counts.

Results

Of 50 children screened, 31 with a median age of 13 months were included. Most (80.6%) were from lower socio-economic backgrounds. Limb tremors were observed in 51.6%, and all but one child had a developmental quotient (DQ) below 70, indicating significant developmental delays. Microcephaly was present in 35.4%, and moderate to severe anaemia was nearly universal. Growth parameters, including fat mass and fat-free mass, were significantly lower in children with ITS compared to controls. Lipid profiles revealed consistently high triglycerides, low HDL and elevated LDL in most age groups, suggesting a pro-atherogenic metabolic state.

Conclusion

Severe Infantile vitamin B12 deficiency significantly impairs head growth, overall development and body composition, with potential long-term cardiovascular risks due to abnormal lipid profiles.

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婴儿维生素B12缺乏症儿童身体成分的研究。

背景：婴儿震颤综合征（ITS），或神经皮肤婴儿维生素B12缺乏症（NIBS），以震颤、发育迟缓、贫血和皮肤色素沉着为特征。本研究旨在评估ITS患儿的体成分和血脂。方法：纳入临床诊断为ITS的2岁以下儿童。研究人员记录了饮食史、发育里程碑和人体测量数据，以及血液中B12、同型半胱氨酸、血脂和血细胞计数的检测结果。结果：在筛选的50名儿童中，31名中位年龄为13个月。大多数（80.6%）来自较低的社会经济背景。51.6%的儿童出现肢体震颤，除1名儿童外，其余儿童的发育商（DQ）均低于70，表明发育明显迟缓。小头畸形占35.4%，中度至重度贫血几乎普遍存在。ITS患儿的生长参数，包括脂肪量和无脂肪量，与对照组相比显著降低。脂质谱显示，在大多数年龄组中，甘油三酯持续高，HDL低，LDL升高，表明存在促动脉粥样硬化代谢状态。结论：严重的婴儿维生素B12缺乏症会显著损害头部生长、整体发育和身体组成，并因血脂异常而具有潜在的长期心血管风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of paediatrics and child health 医学-小儿科

CiteScore

2.90

自引率

5.90%

发文量

487

审稿时长

3-6 weeks

期刊介绍： The Journal of Paediatrics and Child Health publishes original research articles of scientific excellence in paediatrics and child health. Research Articles, Case Reports and Letters to the Editor are published, together with invited Reviews, Annotations, Editorial Comments and manuscripts of educational interest.