Ex-vivo 7T MRI of human explanted cirrhotic liver with HCC: quantitative and qualitative evaluation with radiological-pathological correlation.

IF 9.7 1区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Radiologia Medica Pub Date : 2025-02-12 DOI:10.1007/s11547-025-01962-8

Rosa Cervelli, Matteo Cencini, Giacomo Aringhieri, Beatrice Silvestrini, Andrea Cacciato Insilla, Daniela Campani, Davide Ghinolfi, Paolo De Simone, Michela Tosetti, Laura Crocetti

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引用次数: 0

Abstract

Introduction: Hepatocellular carcinoma's (HCC) pathological grading is a recognized factor influencing intrahepatic recurrence after treatment. Thus, understanding the HCC heterogeneity is crucial to select the best treatment option aiming at personalized medicine. 7T MRI can provide qualitative and quantitative data, potentially identifying imaging biomarkers for lesions characterization.

Materials and methods: From May 2019 to December 2019, all explanted livers of patients undergoing liver transplant were enrolled. All patients underwent whole body CT before liver transplant and all the explanted livers were evaluated (ex-vivo) by 7T MRI within 12 h from liver removal with qualitative and quantitative acquisitions, including 2D/3D magnetic resonance fingerprinting (MRF). First, two expert radiologists qualitatively and quantitatively evaluated the imaging data focusing on both lesions and surrounding tissue, comparing conventional and MRF sequences. Then, specimens were evaluated by an expert pathologist regarding both liver tissues and lesions, particularly focusing on HCC grading.

Conclusions: This work may represent the first step supporting the introduction of quantitative MR imaging (including MRF) in the clinical practice. Along with conventional protocol and dynamic contrast enhancement, the integration of quantitative MR imaging can provide imaging biomarkers useful to identify HCC lesions more prone to recurrence, leading to a better patient selection, according to a personalized medicine approach.

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来源期刊

Radiologia Medica 医学-核医学

CiteScore

14.10

自引率

7.90%

发文量

133

审稿时长

4-8 weeks

期刊介绍： Felice Perussia founded La radiologia medica in 1914. It is a peer-reviewed journal and serves as the official journal of the Italian Society of Medical and Interventional Radiology (SIRM). The primary purpose of the journal is to disseminate information related to Radiology, especially advancements in diagnostic imaging and related disciplines. La radiologia medica welcomes original research on both fundamental and clinical aspects of modern radiology, with a particular focus on diagnostic and interventional imaging techniques. It also covers topics such as radiotherapy, nuclear medicine, radiobiology, health physics, and artificial intelligence in the context of clinical implications. The journal includes various types of contributions such as original articles, review articles, editorials, short reports, and letters to the editor. With an esteemed Editorial Board and a selection of insightful reports, the journal is an indispensable resource for radiologists and professionals in related fields. Ultimately, La radiologia medica aims to serve as a platform for international collaboration and knowledge sharing within the radiological community.