Melatonin alleviates oral epithelial cell inflammation via Keap1/Nrf2 signaling.

IF 2.6 3区医学 International Journal of Immunopathology and Pharmacology Pub Date : 2025-01-01 DOI:10.1177/03946320251318147

Nan Zhang, Wenjing Wang, Rongxia Zhang, Yaxuan Liu, Yamei Wang, Yang Bai, Chencong Li

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Abstract

Background: Oral mucosal diseases manifest primarily as inflammatory conditions. These diseases affect approximately half a billion people worldwide.

Objective: Novel and effective strategies for treating inflammatory diseases of the oral mucosa have great potential for improving patient outcomes, and warrant study.

Methods: The impact of melatonin on inflammation was investigated using RAW264.7 macrophages and HOEC and HSC-3 oral epithelial cells.

Results: Melatonin decreased macrophage-induced inflammation by acting through the melatonin receptor MTNR1A. Additionally, melatonin mitigated macrophage-induced inflammation in oral epithelial cells. Importantly, the results demonstrated that the effects of melatonin on oral epithelial inflammation were mediated through the KEAP1/Nrf2 signaling pathway.

Conclusion: These findings will contribute to the development of innovative therapies for inflammatory conditions affecting the oral epithelium.

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褪黑素通过Keap1/Nrf2信号通路缓解口腔上皮细胞炎症。

背景：口腔黏膜疾病主要表现为炎症。这些疾病影响全世界大约5亿人。目的：新的有效的口腔黏膜炎症性疾病治疗策略有很大的改善患者预后的潜力，值得研究。方法：采用RAW264.7巨噬细胞和HOEC、HSC-3口腔上皮细胞研究褪黑素对炎症的影响。结果：褪黑素通过褪黑素受体MTNR1A降低巨噬细胞诱导的炎症。此外，褪黑素减轻了巨噬细胞诱导的口腔上皮细胞炎症。重要的是，结果表明褪黑素对口腔上皮炎症的作用是通过KEAP1/Nrf2信号通路介导的。结论：这些发现将有助于开发影响口腔上皮炎症的创新疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International Journal of Immunopathology and Pharmacology Immunology and Microbiology-Immunology

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期刊介绍： International Journal of Immunopathology and Pharmacology is an Open Access peer-reviewed journal publishing original papers describing research in the fields of immunology, pathology and pharmacology. The intention is that the journal should reflect both the experimental and clinical aspects of immunology as well as advances in the understanding of the pathology and pharmacology of the immune system.