Melatonin alleviates oral epithelial cell inflammation via Keap1/Nrf2 signaling.

IF 3.5 3区医学 International Journal of Immunopathology and Pharmacology Pub Date : 2025-01-01 DOI:10.1177/03946320251318147

Nan Zhang, Wenjing Wang, Rongxia Zhang, Yaxuan Liu, Yamei Wang, Yang Bai, Chencong Li

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Abstract

Background: Oral mucosal diseases manifest primarily as inflammatory conditions. These diseases affect approximately half a billion people worldwide.

Objective: Novel and effective strategies for treating inflammatory diseases of the oral mucosa have great potential for improving patient outcomes, and warrant study.

Methods: The impact of melatonin on inflammation was investigated using RAW264.7 macrophages and HOEC and HSC-3 oral epithelial cells.

Results: Melatonin decreased macrophage-induced inflammation by acting through the melatonin receptor MTNR1A. Additionally, melatonin mitigated macrophage-induced inflammation in oral epithelial cells. Importantly, the results demonstrated that the effects of melatonin on oral epithelial inflammation were mediated through the KEAP1/Nrf2 signaling pathway.

Conclusion: These findings will contribute to the development of innovative therapies for inflammatory conditions affecting the oral epithelium.

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International Journal of Immunopathology and Pharmacology Immunology and Microbiology-Immunology

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期刊介绍： International Journal of Immunopathology and Pharmacology is an Open Access peer-reviewed journal publishing original papers describing research in the fields of immunology, pathology and pharmacology. The intention is that the journal should reflect both the experimental and clinical aspects of immunology as well as advances in the understanding of the pathology and pharmacology of the immune system.