The Efficacy of Pediatric-Inspired Regimens vs. Hyper-CVAD in the Treatment of Adolescents and Young Adults With Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis
Wenqing Su, Melisa Stricherz, Alison Martin, Jonathan Belsey, Eric Kemadjou, Daniel J. DeAngelo
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引用次数: 0
Abstract
Adults with acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL) have poorer outcomes than pediatric patients. The aim of this systematic literature review and meta-analysis was to compare asparaginase (ASP)-containing pediatric-inspired regimens (PIRs) with hyper-fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper-CVAD) in adolescents and young adults (AYAs) with ALL/LBL. Searches included relevant publications up to April 21, 2022. A meta-analysis was conducted in four studies with comparable demographics, to estimate the effects of intervention on rates of response and survival. Patients receiving PIRs were approximately twice as likely to achieve complete response and 1.8 times more likely to survive than patients receiving hyper-CVAD. These results suggest ASP-containing PIRs are associated with improved outcomes in AYAs compared with hyper-CVAD.
期刊介绍：
The American Journal of Hematology offers extensive coverage of experimental and clinical aspects of blood diseases in humans and animal models. The journal publishes original contributions in both non-malignant and malignant hematological diseases, encompassing clinical and basic studies in areas such as hemostasis, thrombosis, immunology, blood banking, and stem cell biology. Clinical translational reports highlighting innovative therapeutic approaches for the diagnosis and treatment of hematological diseases are actively encouraged.The American Journal of Hematology features regular original laboratory and clinical research articles, brief research reports, critical reviews, images in hematology, as well as letters and correspondence.
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