Traditional Chinese medicine provides candidates for mutiple seclorsis: A review based on the progress of MS and potent treatment medicine

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY Multiple sclerosis and related disorders Pub Date : 2025-03-01 Epub Date: 2025-02-08 DOI:10.1016/j.msard.2025.106319

Shaopeng Zhai , Yan Chen , Taotao Jiang , Fengjuan Wu , Xiaorong Cheng , Qi Wang , Manxia Wang

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Abstract

Multiple Sclerosis(MS) is a chronic inflammatory and degenerative autoimmune neurological disease, characterized by immune cells infiltration, demyelination, axonal loss and neuron degeneration. At present, the precise mechanism of the disease is still not very clear. Latest studies clarified that immune imbalance, microglia polarization, oxidative stress, the destruction of blood-brain barrier(BBB) and blood-spinal cord barrier(BSCB), and intestinal flora imbalance may participate in the pathogenesis and promote the progress of the disease. Traditional Chinese medicine(TCM) and their bioeffective components were found to have capacity to regulate these mechanisms, and have the advantages of multi-target activity, low toxicity and side effects, making TCM promising therapy candidates. In this review, we summarized the progress of TCM in treating MS or its animal model in recent five years, in order to further demonstrate the mechanism of MS and provide more potential effective drug choice.

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中医为多发性闭锁提供候选者：基于多发性硬化症进展和有效治疗药物的综述

多发性硬化症（MS）是一种慢性炎症性和退行性自身免疫性神经系统疾病，以免疫细胞浸润、脱髓鞘、轴突丧失和神经元变性为特征。目前，该病的确切发病机制仍不十分清楚。最新研究表明，免疫失衡、小胶质细胞极化、氧化应激、血脑屏障（BBB）和血脊髓屏障（BSCB）破坏、肠道菌群失衡等可能参与了该病的发病机制，促进了疾病的进展。中药及其生物有效成分具有调节这些机制的能力，并且具有多靶点活性、低毒副作用的优势，使中药成为有前景的治疗候选药物。本文就近5年来中医药治疗多发性硬化症及其动物模型的研究进展进行综述，以期进一步阐明多发性硬化症的发病机制，提供更多潜在的有效药物选择。

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来源期刊

Multiple sclerosis and related disorders CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

20.00%

发文量

814

审稿时长

66 days

期刊介绍： Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource. A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.