De-Dong Zhou , Yuan-Yuan Bai , Yuan-Yi Lin , Xiao-Dong Zhao , Zhi-Yuan Lu , Zhi-Wei Wang , Xiao-Jing Wang
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引用次数: 0
Abstract
Three new monoterpene indole alkaloids (1–3) together with eight known alkaloids (4–11) were isolated from the fruits of Bousigonia mekongensis. Compounds 1 and 2 were the first examples of akuammicine-Aspidosperma type bisindole alkaloids. Their structures were elucidated by NNR spectra, MS data and electronic circular dichroism (ECD) spectra. All compounds were evaluated for their cytotoxic activity against HepG2 liver cancer cells in vitro. Compounds 1, 4, 9 and 11 showed antiproliferative activity with IC50 values of 15.74 ± 1.37, 8.55 ± 0.97, 9.23 ± 1.11, and 0.80 ± 0.44 μM, respectively (0.51 ± 0.14 μM for the control, doxorubicin).
期刊介绍：
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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