Case of severe thrombocytopenia with recurrent extensive deep vein thrombosis due to antiphospholipid syndrome, management challenge

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL Clinical Case Reports Pub Date : 2025-02-13 DOI:10.1002/ccr3.9430
Bassem Al Hariri, Gaydaa Ali Ahmed Ali, Arwa Elfatih Mohamed Ali, Mohamed Elfatih MohamedAli, Feroz Jenner Poolakundan, Muhammad Sharif, Memon Noor Illahi
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Abstract

Severe thrombocytopenia in secondary antiphospholipid syndrome (APS) presents a significant management challenge. This case highlights the complexity of managing APS-related thrombocytopenia, requiring a nuanced approach to balancing bleeding and thrombotic risks. Intravenous immunoglobulin, followed by a short course of steroids, successfully increased platelet counts without adverse bleeding or thrombotic events. Initiating therapeutic anticoagulation with Warfarin was delayed until platelet counts exceeded 50 × 10^3/μL, emphasizing the cautious approach required in such cases to mitigate thrombotic risks while avoiding bleeding complications.

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抗磷脂综合征所致严重血小板减少伴复发性广泛深静脉血栓1例,治疗挑战
继发性抗磷脂综合征(APS)的严重血小板减少症提出了一个重大的管理挑战。本病例强调了管理aps相关血小板减少症的复杂性,需要一种微妙的方法来平衡出血和血栓形成的风险。静脉注射免疫球蛋白,再加上短期类固醇治疗,成功地增加了血小板计数,没有出现不良出血或血栓事件。在血小板计数超过50 × 10^3/μL后才开始使用华法林抗凝治疗,强调在这种情况下需要谨慎处理,以减轻血栓形成风险,同时避免出血并发症。
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来源期刊
Clinical Case Reports
Clinical Case Reports MEDICINE, GENERAL & INTERNAL-
自引率
14.30%
发文量
1268
审稿时长
13 weeks
期刊介绍: Clinical Case Reports is different from other case report journals. Our aim is to directly improve global health and increase clinical understanding using case reports to convey important best practice information. We welcome case reports from all areas of Medicine, Nursing, Dentistry, and Veterinary Science and may include: -Any clinical case or procedure which illustrates an important best practice teaching message -Any clinical case or procedure which illustrates the appropriate use of an important clinical guideline or systematic review. As well as: -The management of novel or very uncommon diseases -A common disease presenting in an uncommon way -An uncommon disease masquerading as something more common -Cases which expand understanding of disease pathogenesis -Cases where the teaching point is based on an error -Cases which allow us to re-think established medical lore -Unreported adverse effects of interventions (drug, procedural, or other).
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