The Recruitment and Immune Suppression Mechanisms of Myeloid-Derived Suppressor Cells and Their Impact on Bone Metastatic Cancer

IF 1.5 Q4 ONCOLOGY Cancer reports Pub Date : 2025-02-13 DOI:10.1002/cnr2.70044

Chengyuan Li, Yucheng Xue, Eloy Yinwang, Zhaoming Ye

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Abstract

Background

MDSCs are immature neutrophils and monocytes with immunosuppressive potentials, involving mononuclear MDSCs (M-MDSCs) and polymorphonuclear MDSCs (PMN-MDSCs).

Recent Findings

They are significant components of the tumor microenvironment (TME). Besides, recent studies also verified that MDSCs also facilitated the progression of bone metastasis by regulating the network of cytokines and the function of immune cells.