The Recruitment and Immune Suppression Mechanisms of Myeloid-Derived Suppressor Cells and Their Impact on Bone Metastatic Cancer

IF 1.9 Q4 ONCOLOGY Cancer reports Pub Date : 2025-02-13 DOI:10.1002/cnr2.70044

Chengyuan Li, Yucheng Xue, Eloy Yinwang, Zhaoming Ye

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Abstract

Background

MDSCs are immature neutrophils and monocytes with immunosuppressive potentials, involving mononuclear MDSCs (M-MDSCs) and polymorphonuclear MDSCs (PMN-MDSCs).

Recent Findings

They are significant components of the tumor microenvironment (TME). Besides, recent studies also verified that MDSCs also facilitated the progression of bone metastasis by regulating the network of cytokines and the function of immune cells.

Conclusion

It is necessary to summarize the mechanisms of MDSC recruitment and immunosuppression, and their impact on bone metastasis.

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骨髓源性抑制细胞的募集和免疫抑制机制及其对骨转移癌的影响

MDSCs是具有免疫抑制潜能的未成熟中性粒细胞和单核细胞，包括单核MDSCs （M-MDSCs）和多形核MDSCs （PMN-MDSCs）。它们是肿瘤微环境（TME）的重要组成部分。此外，最近的研究也证实了MDSCs还通过调节细胞因子网络和免疫细胞功能促进骨转移的进展。结论有必要对骨髓间充质干细胞募集和免疫抑制的机制及其对骨转移的影响进行总结。

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