The Pathophysiological Role of Mitochondria-associated Membranes in Coronary Artery Disease and Atherosclerosis.

IF 3.5 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Current medicinal chemistry Pub Date : 2026-01-01 DOI:10.2174/0109298673343245250128093845

Junyan Zhang, Zhongxiu Chen, Li Rao, Yong He

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Abstract

Mitochondria-associated membranes (MAMs) are pivotal in cellular homeostasis, mediating communication between the endoplasmic reticulum and mitochondria. They are increasingly recognized for their role in atherosclerosis and coronary artery disease (CAD). This review delves into the cellular perspective of MAMs' impact on atherosclerosis and CAD, highlighting their influence on disease progression and the potential for therapeutic intervention. MAMs are implicated in key pathophysiological processes such as the generation of reactive oxygen species, calcium homeostasis, myocardial ischemia-reperfusion injury, autophagy, lipid synthesis and transport, and energy metabolism-fundamental to the development and progression of atherosclerosis and CAD. The complex interplay of MAMs with these pathological processes underscores their potential as therapeutic targets. This review synthesizes current understanding and emphasizes the need for further research to elucidate the multifaceted roles of MAMs in atherosclerosis and CAD, offering avenues for developing novel strategies aimed at improving mitochondrial health and mitigating the impact of these conditions.

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线粒体相关膜在冠状动脉疾病和动脉粥样硬化中的病理生理作用。

线粒体相关膜（MAMs）在细胞稳态中起关键作用，介导内质网和线粒体之间的通讯。它们在动脉粥样硬化和冠状动脉疾病（CAD）中的作用越来越得到认可。这篇综述从细胞角度探讨了MAMs对动脉粥样硬化和CAD的影响，强调了它们对疾病进展的影响和治疗干预的潜力。MAMs参与关键的病理生理过程，如活性氧的产生、钙稳态、心肌缺血-再灌注损伤、自噬、脂质合成和转运以及能量代谢，这些都是动脉粥样硬化和冠心病发生和发展的基础。MAMs与这些病理过程的复杂相互作用强调了它们作为治疗靶点的潜力。这篇综述综合了目前的理解，并强调需要进一步的研究来阐明MAMs在动脉粥样硬化和冠心病中的多方面作用，为开发旨在改善线粒体健康和减轻这些疾病影响的新策略提供途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current medicinal chemistry 医学-生化与分子生物学

CiteScore

8.60

自引率

2.40%

发文量

468

审稿时长

3 months

期刊介绍： Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.