Exploring m6A modifications in gastric cancer: from molecular mechanisms to clinical applications.

IF 3.4 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL European Journal of Medical Research Pub Date : 2025-02-12 DOI:10.1186/s40001-025-02353-5

Penghui Li, Xiangjie Fang, Di Huang

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Abstract

The significance of m6A modifications in several biological processes has been increasingly recognized, particularly in the context of cancer. For instance, m6A modifications in gastric cancer (GC) have been significantly implicated in tumor progression, metastasis, and treatment resistance. GC is characterized by the differential expression of m6A regulators. High expression writers such as METTL3 and WTAP are associated with poor prognosis and aggressive clinical features. Conversely, low expression of METTL14 is linked to worse clinical outcomes, whereas elevated levels of demethylases, such as FTO and ALKBH5, correlate with better survival rates. These m6A regulators influence several cellular biological functions, including proliferation, invasion, migration, glycolysis, and chemotherapy resistance, thereby affecting tumor growth and therapeutic outcomes. The assessment of m6A modification patterns and the expression profiles of m6A-related genes hold substantial potential for improving the clinical diagnosis and treatment of GC. In this review, we provide an updated and comprehensive summary of the role of m6A modifications in GC, emphasizing their molecular mechanisms, clinical significance, and translational applications in developing novel diagnostic and therapeutic strategies.

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探讨胃癌中m6A修饰：从分子机制到临床应用

m6A修饰在几个生物学过程中的重要性已被越来越多地认识到，特别是在癌症的背景下。例如，胃癌（GC）中的m6A修饰与肿瘤进展、转移和治疗耐药性有显著关系。GC以m6A调节因子的差异表达为特征。高表达作家如METTL3和WTAP与预后差和侵袭性临床特征相关。相反，METTL14的低表达与较差的临床结果相关，而去甲基化酶（如FTO和ALKBH5）的升高水平与较好的生存率相关。这些m6A调节因子影响多种细胞生物学功能，包括增殖、侵袭、迁移、糖酵解和化疗耐药性，从而影响肿瘤生长和治疗结果。评估m6A修饰模式和m6A相关基因的表达谱对改善GC的临床诊断和治疗具有重要的潜力。在这篇综述中，我们对m6A修饰在GC中的作用进行了最新和全面的总结，强调了它们的分子机制、临床意义以及在开发新的诊断和治疗策略方面的转化应用。

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来源期刊

European Journal of Medical Research 医学-医学：研究与实验

CiteScore

3.20

自引率

0.00%

发文量

247

审稿时长

>12 weeks

期刊介绍： European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.