Risk Factors Associated With the Development of Late Pulmonary Artery Hypertension in Extremely Premature Infants.

IF 2.7 3区医学 Q1 PEDIATRICS Pediatric Pulmonology Pub Date : 2025-02-01 DOI:10.1002/ppul.27501

Paige E Condit, John S Hokanson, Vivek Balasubramaniam, David J McCulley, Michael Lasarev, Luke Lamers, Ryan M McAdams, Dinushan C Kaluarachchi

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Abstract

Objective: To identify risk factors for late pulmonary artery hypertension (PH) at 36 weeks' postmenstrual age (PMA) in infants born before 28 weeks' gestation.

Design/methods: A retrospective cohort study included infants born < 28 weeks' gestation who underwent PH screening echocardiography at 36 weeks' PMA. We compared characteristics between infants with and without late PH to determine associations.

Results: Of 99 infants, 20 (20%) developed late PH. The FiO2% requirement at 4 weeks of age, home oxygen use, and procedural patent ductus arteriosus closure were associated with late PH. Bronchopulmonary dysplasia (BPD) severity was linearly associated with late PH, with each 1-point increase in BPD severity corresponding to a 3.5-fold increased odds of late PH diagnosis.

Conclusion(s): One in five extremely premature infants developed late PH. Markers of respiratory disease severity, including the BPD grade, were associated with the development of late PH.

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来源期刊

Pediatric Pulmonology 医学-呼吸系统

CiteScore

6.00

自引率

12.90%

发文量

468

审稿时长

3-8 weeks

期刊介绍： Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases. PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.