[Genetic testing of carriers with Robertsonian translocations before embryo implantation and associated clinical outcomes].

Q3 Medicine Zhonghua yi xue za zhi Pub Date : 2025-02-11 DOI:10.3760/cma.j.cn112137-20240729-01746

M Y Ma, Y Z Yang, C Z Lu, P P Xu, M Zhang, Z W Bian, W H Yang, H T Zhang, Y X Zhang, J L Guo, S Mu, L Y Gao, H M Peng

{"title":"[Genetic testing of carriers with Robertsonian translocations before embryo implantation and associated clinical outcomes].","authors":"M Y Ma, Y Z Yang, C Z Lu, P P Xu, M Zhang, Z W Bian, W H Yang, H T Zhang, Y X Zhang, J L Guo, S Mu, L Y Gao, H M Peng","doi":"10.3760/cma.j.cn112137-20240729-01746","DOIUrl":null,"url":null,"abstract":"A total of 112 carriers (51 males and 61 females) with Robertsonian translocations who underwent 148 cycles of preimplantation genetic testing for structural rearrangements (PGT-SR) between February 2017 and December 2023 at the First Center of General Hospital of Chinese PLA were recruited. The heterologous type rob (13; 14) was the most common form of translocation, which accounted for 65.2% (73/112). The total euploidy rate of blastocysts was 42.1% (303/720). Male carriers had higher rate of euploid embryo than female carriers [50.0% (149/298) vs 36.5% (154/422), P<0.001]. Likewise, the clinical pregnancy rate in male carriers was higher than female carriers, but the difference was not statistically significant [62.9% (39/62) vs 49.4% (38/77), P=0.154]. There were 139 transferrable embryos, with a clinical pregnancy rate of 55.4% (77/139) and abortion rate of 14.3% (11/77). The current study indicates that male carriers with Robertsonian translocations had higher rate of euploid embryo than female carriers in PGT-SR cycles.","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 6","pages":"465-468"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhonghua yi xue za zhi","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3760/cma.j.cn112137-20240729-01746","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

A total of 112 carriers (51 males and 61 females) with Robertsonian translocations who underwent 148 cycles of preimplantation genetic testing for structural rearrangements (PGT-SR) between February 2017 and December 2023 at the First Center of General Hospital of Chinese PLA were recruited. The heterologous type rob (13; 14) was the most common form of translocation, which accounted for 65.2% (73/112). The total euploidy rate of blastocysts was 42.1% (303/720). Male carriers had higher rate of euploid embryo than female carriers [50.0% (149/298) vs 36.5% (154/422), P<0.001]. Likewise, the clinical pregnancy rate in male carriers was higher than female carriers, but the difference was not statistically significant [62.9% (39/62) vs 49.4% (38/77), P=0.154]. There were 139 transferrable embryos, with a clinical pregnancy rate of 55.4% (77/139) and abortion rate of 14.3% (11/77). The current study indicates that male carriers with Robertsonian translocations had higher rate of euploid embryo than female carriers in PGT-SR cycles.

查看原文