T I Baranich, A S Averchuk, M V Kukla, N A Rozanova, A V Stavrovskaya, V V Glinkina, V S Sukhorukov, A B Salmina
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引用次数: 0
Abstract
Angiogenesis is regulated by various types of endothelial cells: tip cells, stalk cells, and phalanx cells. In this study, the changes in cerebral angiogenesis and the characteristics of angiogenesis in the prefrontal cortex of Alzheimer's disease (AD) mice were investigated. AD was induced by injection of β-amyloid into the hippocampus. The animals underwent cognitive testing, and their brains were analyzed using immunohistochemical techniques to evaluate angiogenesis. The results showed an increase in the proliferation of endothelial cells and altered ratio of tip, stalk, and phalanx cells. Vascular branching and density in the prefrontal cortex were decreased, indicating an unproductive form of angiogenesis in AD. Obtained results highlight the link between changes in angiogenesis and cognitive decline, confirming the importance of vascular dysfunction in AD progression.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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