Mitochondrial Dysfunction: Potential Therapy For Abdominal Aortic Aneurysms.

IF 2.1 3区医学 Q2 PERIPHERAL VASCULAR DISEASE Current vascular pharmacology Pub Date : 2025-01-01 DOI:10.2174/0115701611312293241220101556

Wenfan Yang, Jianxiong He, Hao Yu, Ya Wu, Sen Shi

引用次数: 0

Abstract

Abdominal Aortic Aneurysm (AAA) is a life-threatening vascular disease. Despite advancements in understanding the pathogenesis of AAA, significant knowledge gaps persist. Recent evidence increasingly implicates mitochondrial dysfunction as a contributing factor that exacerbates AAA, inducing further expansion of aneurysm, rupture, and subsequent death. This review summarizes the latest research findings and theories associated with AAA pathogenesis, with a particular focus on mitochondrial dysfunction in AAA, including mitochondrial quality control, mitochondrial membrane potential, mitochondrial morphology, oxidation and antioxidation, normal functioning of the respiratory chain, mitochondrial mutations, and the regulation of other mitochondrial signaling pathways. Moreover, we highlight potential medical interventions based on regulating mitochondrial function for AAA treatment.

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线粒体功能障碍：腹主动脉瘤的潜在治疗方法。

腹主动脉瘤（AAA）是一种危及生命的血管疾病。尽管对AAA发病机制的了解有所进展，但仍存在显著的知识差距。最近越来越多的证据表明，线粒体功能障碍是加剧AAA的一个因素，可诱发动脉瘤进一步扩大、破裂和随后的死亡。本文综述了AAA发病机制的最新研究成果和相关理论，重点介绍了AAA的线粒体功能障碍，包括线粒体质量控制、线粒体膜电位、线粒体形态、氧化和抗氧化、呼吸链正常功能、线粒体突变以及其他线粒体信号通路的调控。此外，我们强调了基于调节线粒体功能的潜在医疗干预，以治疗AAA。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current vascular pharmacology 医学-外周血管病

CiteScore

9.20

自引率

4.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Vascular Pharmacology publishes clinical and research-based reviews/mini-reviews, original research articles, letters, debates, drug clinical trial studies and guest edited issues to update all those concerned with the treatment of vascular disease, bridging the gap between clinical practice and ongoing research. Vascular disease is the commonest cause of death in Westernized countries and its incidence is on the increase in developing countries. It follows that considerable research is directed at establishing effective treatment for acute vascular events. Long-term treatment has also received considerable attention (e.g. for symptomatic relief). Furthermore, effective prevention, whether primary or secondary, is backed by the findings of several landmark trials. Vascular disease is a complex field with primary care physicians and nurse practitioners as well as several specialties involved. The latter include cardiology, vascular and cardio thoracic surgery, general medicine, radiology, clinical pharmacology and neurology (stroke units).