Youjia Zhang , Xiaoguang Ge , Shi Gao , Jibin Song
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引用次数: 0
Abstract
Gold nanorods (AuNRs) have become promising as radiosensitizers and photoacoustic (PA) imaging agents due to their strong X-ray attenuation ability and adjustable near-infrared (NIR) absorption. However, there remains room to further improve AuNRs for the imaging and treatment of tumors. We developed a biomarker responsive AuNR-based Janus nanoprobe by integrating MnO2 on one end of the AuNRs and specific ligands on the other end. In the tumor microenvironment, highly expressed transglutaminase (TGase), which facilitates the formation of isopeptide linkages between glutamine (Gln) and lysine (Lys), induces the aggregation of AuNRs. This in-situ aggregation amplifies the PA signal, extends the time window for PA imaging and enhances the radiosensitization effect. Meanwhile, the highly expressed glutathione (GSH) in tumors degrades MnO2 which triggers a chemodynamic treatment.
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The Journal of Controlled Release (JCR) proudly serves as the Official Journal of the Controlled Release Society and the Japan Society of Drug Delivery System.
Dedicated to the broad field of delivery science and technology, JCR publishes high-quality research articles covering drug delivery systems and all facets of formulations. This includes the physicochemical and biological properties of drugs, design and characterization of dosage forms, release mechanisms, in vivo testing, and formulation research and development across pharmaceutical, diagnostic, agricultural, environmental, cosmetic, and food industries.
Priority is given to manuscripts that contribute to the fundamental understanding of principles or demonstrate the advantages of novel technologies in terms of safety and efficacy over current clinical standards. JCR strives to be a leading platform for advancements in delivery science and technology.
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