Nocturnal Light Pollution Synergistically Impairs Glucose Metabolism With Age and Weight in Monkeys.

IF 3.4 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Journal of Diabetes Research Pub Date : 2024-12-10 eCollection Date: 2024-01-01 DOI:10.1155/2024/5112055
Shuxing Wang, Xuange Cheng, Zihao Liang, Zhenyi Chen, Jiankai Zhang, Qiang Xu
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Abstract

Over the past decades, the global prevalence of Type 2 diabetes mellitus (T2D) and impaired glucose tolerance (IGT) has been increasing at an epidemic rate, yet the exact cause remains unknown. It is widely accepted that glucose metabolism can be impaired by circadian rhythms and sleep disturbances. Concurrently, exposures to light at night have been closely linked to circadian and sleep disturbances. However, there is no direct experiment on primates to demonstrate the precise extent of how serious light pollution impairs glucose metabolism, whether people will eventually become accustomed to this environment, and whether the pollution has synergistic impairing effects with aging and weight on glucose metabolism. To quantitatively address these questions, 137 cynomolgus were exposed to three distinct nocturnal light intensities for consecutive 10 months. Monthly glucose metabolism assessments were conducted. Data pertaining to the mortality rate of preexisting diabetes, incidence of light-induced diabetes and IGT, and alterations in insulin secretion were collected and analyzed. The results show that nocturnal light (1) caused premature deaths in individuals with preexisting diabetes; (2) intensity-dependently induced diabetes and IGT in previous healthy monkeys; (3) intensity-dependently reduced melatonin secretion; (4) had a synergistic impairing effect on glucose metabolism with aging and weight; and (5) although monkeys would eventually adapt to the environment, the disrupted glucose metabolism would not fully recover in most individuals. In conclusion, nocturnal light is associated with the global high prevalence of T2D and IGT. The harmful effects of light pollution on glucose metabolism are synergistic with age and weight.

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夜间光污染协同损害猴子随年龄和体重的葡萄糖代谢。
在过去的几十年里,2型糖尿病(T2D)和糖耐量受损(IGT)的全球患病率一直在以流行病的速度增加,但确切的原因仍然未知。人们普遍认为,昼夜节律和睡眠障碍会损害葡萄糖代谢。同时,夜间暴露在光线下与昼夜节律和睡眠障碍密切相关。然而,目前还没有直接在灵长类动物身上进行的实验来证明光污染对葡萄糖代谢的损害程度有多严重,人们最终是否会习惯这种环境,以及光污染是否与衰老和体重对葡萄糖代谢有协同损害作用。为了定量地回答这些问题,137只食蟹连续10个月暴露在三种不同的夜间光强度下。每月进行葡萄糖代谢评估。收集并分析了与既往糖尿病死亡率、光致糖尿病和IGT发生率以及胰岛素分泌改变有关的数据。结果表明,夜间光照(1)导致糖尿病患者过早死亡;(2)先前健康猴子强度依赖性诱导的糖尿病和IGT;(3)强度依赖性褪黑激素分泌减少;(4)随着年龄和体重的增加,对糖代谢有协同抑制作用;(5)尽管猴子最终会适应环境,但大多数个体的葡萄糖代谢紊乱并不能完全恢复。总之,夜间光照与全球高患病率的T2D和IGT有关。光污染对糖代谢的影响与年龄和体重呈协同效应。
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来源期刊
Journal of Diabetes Research
Journal of Diabetes Research ENDOCRINOLOGY & METABOLISM-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
8.40
自引率
2.30%
发文量
152
审稿时长
14 weeks
期刊介绍: Journal of Diabetes Research is a peer-reviewed, Open Access journal that publishes research articles, review articles, and clinical studies related to type 1 and type 2 diabetes. The journal welcomes submissions focusing on the epidemiology, etiology, pathogenesis, management, and prevention of diabetes, as well as associated complications, such as diabetic retinopathy, neuropathy and nephropathy.
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