Felipe T de Freitas Barão, Gina C Rocha Silvestre, Alexandre Queiroz Silva, Erasmo Simão da Silva
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引用次数: 0
Abstract
Aortic aneurysm (AA) is clinically important, but its causes remain unclear. Smoking is consistently linked to AA, while diabetes shows a negative association despite being a risk factor for atherosclerosis. Biomechanical and histological studies of the aortic wall may provide insights. In our study, 75 rats were divided into control, smoker, diabetic, and diabetic smoker groups. After exposure to smoking and diabetes induction, thoracic aorta samples were collected. Biomechanical tests showed lower resistance in diabetic smokers compared to smokers alone. Histological analysis revealed no significant differences in collagen, elastic fibers, or inflammation. Metalloproteinase-9 (MMP-9) activity also showed no significant variation. Despite risk factors, the thoracic aorta may be resilient to aneurysm development, as indicated by its biomechanical properties.
期刊介绍：
The ''Journal of Vascular Research'' publishes original articles and reviews of scientific excellence in vascular and microvascular biology, physiology and pathophysiology. The scope of the journal covers a broad spectrum of vascular and lymphatic research, including vascular structure, vascular function, haemodynamics, mechanics, cell signalling, intercellular communication, growth and differentiation. JVR''s ''Vascular Update'' series regularly presents state-of-the-art reviews on hot topics in vascular biology. Manuscript processing times are, consistent with stringent review, kept as short as possible due to electronic submission. All articles are published online first, ensuring rapid publication. The ''Journal of Vascular Research'' is the official journal of the European Society for Microcirculation. A biennial prize is awarded to the authors of the best paper published in the journal over the previous two years, thus encouraging young scientists working in the exciting field of vascular biology to publish their findings.
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