Association of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and neurogenesis: a systematic review.

IF 2.5 4区医学 Q3 NEUROSCIENCES Acta Neuropsychiatrica Pub Date : 2025-02-14 DOI:10.1017/neu.2025.4

Hezekiah C T Au, Yang Jing Zheng, Gia Han Le, Sabrina Wong, Kayla M Teopiz, Angela T H Kwan, Hartej Gill, Sebastian Badulescu, Kyle Valentino, Joshua D Rosenblat, Rodrigo B Mansur, Roger S McIntyre

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Abstract

Objective: Glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-1 receptor agonist (GLP-1 RA) administration has been associated with neuroproliferative effects and modulatory effects in neuronal pathways. Herein, we conducted a comprehensive synthesis of the effects of GLP-1 and GLP-1 RAs on neurogenesis.

Methods: We examined studies that investigate changes in neurogenesis mediated by GLP-1 and GLP-1 RA administration in both human and animal populations. Relevant articles were retrieved through OVID (MedLine, Embase, AMED, PsychINFO, JBI EBP Database), PubMed, and Web of Science from database inception to July 2nd. Primary studies investigating the role of GLP-1 and GLP-1 RAs on neurogenesis were included for analysis.

Results: GLP-1 and GLP-1 RAs (i.e. exenatide, geniposide, liraglutide, lixisenatide, and semaglutide), increased neurogenesis within the dentate gyrus, hippocampus, olfactory bulb, and the medial striatum in animal models. Additionally, GLP-1 and GLP-1 RAs were associated with modulating changes in multiple apoptotic pathways and upregulating survival pathways.

Discussion: GLP-1 and GLP-1 RAs are positively associated with neurogenesis. This effect may have translational implications insofar as disparate mental disorders that are characterised by neurogenesis defects (e.g. depressive disorders and neurocognitive disorders) may be benefitted by these agents.

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胰高血糖素样肽-1受体激动剂（GLP-1 RAs）与神经发生的关联：系统综述。

目的：胰高血糖素样肽-1 （GLP-1）和胰高血糖素样肽-1受体激动剂（GLP-1 RA）的给药与神经增殖作用和神经元通路的调节作用有关。在此，我们全面综合了GLP-1和GLP-1 RAs对神经发生的影响。方法：我们研究了GLP-1和GLP-1 RA在人和动物群体中介导的神经发生变化的研究。通过OVID （MedLine, Embase， AMED, PsychINFO， JBI EBP数据库），PubMed和Web of Science检索从数据库建立到7月2日的相关文章。对GLP-1和GLP-1 RAs在神经发生中的作用的初步研究纳入分析。结果：在动物模型中，GLP-1和GLP-1 RAs（即艾塞那肽、genipo苷、利拉鲁肽、利昔那肽和semaglutide）增加齿状回、海马、嗅球和内侧纹状体内的神经发生。此外，GLP-1和GLP-1 RAs与调节多种凋亡途径的变化和上调存活途径有关。讨论：GLP-1和GLP-1 RAs与神经发生呈正相关。这种效应可能具有翻译意义，因为以神经发生缺陷为特征的不同精神障碍（例如抑郁症和神经认知障碍）可能受益于这些药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Neuropsychiatrica NEUROSCIENCES-PSYCHIATRY

自引率

5.30%

发文量

期刊介绍： Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.