{"title":"Berberine Derivative B68 Promotes Tumor Immune Clearance by Dual-Targeting BMI1 for Senescence Induction and CSN5 for PD-L1 Degradation (Adv. Sci. 7/2025)","authors":"Hongmei Hu, Qun Wang, Dianping Yu, Xiaoyu Tao, Mengmeng Guo, Saisai Tian, Qing Zhang, Mengting Xu, Xiangxin Geng, Hongwei Zhang, Hanchi Xu, Linyang Li, Shize Xie, Kaixian Chen, Weiliang Zhu, Xu-Wen Li, Hanchen Xu, Bo Li, Weidong Zhang, Sanhong Liu","doi":"10.1002/advs.202570038","DOIUrl":null,"url":null,"abstract":"<p><b>Berberine Derivative B68 Promotes Tumor Immune Clearance</b></p><p>In article number 2413122, Hanchen Xu, Bo Li, Weidong Zhang, Sanhong Liu, and co-workers introduce B68, a berberine derivative, as a dual-targeting cancer treatment. It targets BMI1 to induce senescence and halt tumor growth, and CSN5 to degrade PD-L1, enhancing T-cell attacks on cancer cells. The cover art, inspired by Hou Yi shooting down the suns, symbolizes these dual actions, offering hope for treating colorectal and other cancers.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 7","pages":""},"PeriodicalIF":14.3000,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570038","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Science","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/advs.202570038","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
In article number 2413122, Hanchen Xu, Bo Li, Weidong Zhang, Sanhong Liu, and co-workers introduce B68, a berberine derivative, as a dual-targeting cancer treatment. It targets BMI1 to induce senescence and halt tumor growth, and CSN5 to degrade PD-L1, enhancing T-cell attacks on cancer cells. The cover art, inspired by Hou Yi shooting down the suns, symbolizes these dual actions, offering hope for treating colorectal and other cancers.
期刊介绍：
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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