Cover Feature: Design, Synthesis, and Anti-Prostate Cancer Potential of 2-(4-Nitrobenzyl) Malonates In Vitro and DAL Acute Oral Toxicity Assessment In Vivo (ChemMedChem 4/2025)
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Abstract
2-[(4-Nitrophenyl)methyl]propanedioates and 2-[(4-aminophenyl)methyl]propanedioates were synthesized with malonates and 4-nitrobenzyl bromide as starting materials. The six compounds were spectrophotometrically characterized post-purification and evaluated for their antioxidant, anti-inflammatory, and anticancer properties with a variety of assays. The most potent compound 3c was evaluated for its efficacy in vivo in a Dalton Ascites Lymphoma murine model and evaluated computationally for its apoptosis-inducing abilities. More details can be found in article 10.1002/cmdc.202400371 by Simone Carradori, Prasanna Ramani, and co-workers.
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Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies.
ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs.
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