Min Xiong, Danhao Xia, Honglu Yu, Lanxia Meng, Xingyu Zhang, Jiehui Chen, Ye Tian, Xin Yuan, Xuan Niu, Shuke Nie, Zhaohui Zhang, Chaoyang Liu, Qiang Chen, Keqiang Ye, Zhentao Zhang
{"title":"Microglia Process α-Synuclein Fibrils and Enhance their Pathogenicity in a TREM2-Dependent Manner (Adv. Sci. 7/2025)","authors":"Min Xiong, Danhao Xia, Honglu Yu, Lanxia Meng, Xingyu Zhang, Jiehui Chen, Ye Tian, Xin Yuan, Xuan Niu, Shuke Nie, Zhaohui Zhang, Chaoyang Liu, Qiang Chen, Keqiang Ye, Zhentao Zhang","doi":"10.1002/advs.202570037","DOIUrl":null,"url":null,"abstract":"<p><b>Parkinson's Disease</b></p><p>In article number 2413451, Zhentao Zhang and co-workers show that microglia process α-synuclein fibrils to generate novel fibrils with enhanced toxicity, promoting the onset and progression of Parkinson's disease. α-Synuclein fibrils enter microglia through TREM2. Then they are processed by asparagine endopeptidase to produce α-synuclein 1-103 fibrils, which are more toxic than naive α-synuclein fibrils. These results show that blocking the aberrant activity of microglia halts the progression of Parkinson's disease.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 7","pages":""},"PeriodicalIF":14.3000,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570037","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Science","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/advs.202570037","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Parkinson's Disease
In article number 2413451, Zhentao Zhang and co-workers show that microglia process α-synuclein fibrils to generate novel fibrils with enhanced toxicity, promoting the onset and progression of Parkinson's disease. α-Synuclein fibrils enter microglia through TREM2. Then they are processed by asparagine endopeptidase to produce α-synuclein 1-103 fibrils, which are more toxic than naive α-synuclein fibrils. These results show that blocking the aberrant activity of microglia halts the progression of Parkinson's disease.
期刊介绍：
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
