Integrative Omics Approaches in Cardiovascular Disease Research: Current Trends and Future Directions.

IF 5.8 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Canadian Journal of Cardiology Pub Date : 2025-02-12 DOI:10.1016/j.cjca.2025.02.016
Shekoofeh Saboktakin Rizi, Aleksandra Stamenkovic, Amir Ravandi
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引用次数: 0

Abstract

Cardiovascular disease (CVD) remains the leading cause of death worldwide, necessitating a deeper understanding of its complex pathophysiology. Omics technologies-genomics, transcriptomics, proteomics, and metabolomics-have revolutionized cardiovascular research, enabling high-throughput analysis of biological systems at multiple molecular levels. These tools are advancing precision medicine by uncovering molecular mechanisms underlying CVD. Traditionally, research followed a top-down approach, analyzing broad cardiovascular subsystems. However, modern high-throughput technologies support a bottom-up approach, examining molecular components first and integrating findings into larger systems. This paradigm shift, powered by big data, is transforming cardiovascular research and paving the way for more precise, personalized treatments.

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来源期刊
Canadian Journal of Cardiology
Canadian Journal of Cardiology 医学-心血管系统
CiteScore
9.20
自引率
8.10%
发文量
546
审稿时长
32 days
期刊介绍: The Canadian Journal of Cardiology (CJC) is the official journal of the Canadian Cardiovascular Society (CCS). The CJC is a vehicle for the international dissemination of new knowledge in cardiology and cardiovascular science, particularly serving as the major venue for Canadian cardiovascular medicine.
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