Impact of an antimicrobial stewardship program on the appropriate use of carbapenems in a French university hospital (CARBACAI study)

IF 2.9 4区医学 Q2 INFECTIOUS DISEASES Infectious diseases now Pub Date : 2025-02-13 DOI:10.1016/j.idnow.2025.105039

Julia Santucci , Guillaume Saint-Lorant , Aurélie Baldolli , Christophe Isnard , Pascal Thibon , Arnaud de La Blanchardiere

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Abstract

Objectives

To study compliance with national guidelines for carbapenem (CP) use.

Patients and methods

We performed a two-year prospective monocentric and interventional study in a French university hospital. The study was based on three phases (observation (P1), intervention (P2), and post-intervention (P3)) and ended 10 months after intervention. Compliance of CP prescriptions was based on predetermined criteria.

Results

Among the 330 prescriptions assessed, treatment adequacy on Day 3 increased from 32.3 % (n = 42/130) during phase P1 to 72.2 % (n = 70/97) during phase P3 (p < 0.01), with a significant impact on indications, dosage, and duration of treatment but not on CP choice. There were no significant changes in overall CP consumption.

Conclusions

Implementing an educational antimicrobial stewardship program for hospital CP proper use had a positive impact. Educational reminders are essential to support these improvements.

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