Cervical proprioception, postural control, and pain: unraveling the interconnected challenges in rheumatoid arthritis.

Abstract

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that impairs proprioception and postural control, increasing fall risk and reducing quality of life. This study evaluated cervical proprioception and postural control in RA patients versus asymptomatic individuals, examined their relationship within the RA group, and investigated pain's mediating effects on this association.

Methods: In this cross-sectional study, 82 RA patients and 82 age- and gender-matched controls were recruited. Cervical proprioception was assessed using the Cervical Joint Position Error Test (CJPET), while postural control was evaluated via a stabilometric force platform measuring center-of-pressure length (L CoP), 95% confidence ellipse sway area (ESA 95%), and center-of-pressure velocity (V CoP). Statistical analyses included t-tests, correlation, regression, and mediation analysis to evaluate relationships and the role of pain in cervical proprioception and postural control.

Results: RA patients demonstrated significantly impaired cervical proprioception and postural control compared to controls (p < 0.001). Significant differences were observed in cervical flexion, extension, rotation, and postural control measures (L CoP, ESA 95%, and V CoP; p < 0.001 for all parameters). Pearson's correlations revealed significant relationships between cervical proprioception and postural control parameters. Regression analysis indicated that cervical proprioception, particularly when combined with age and disease duration, significantly predicted postural control. Mediation analysis revealed that pain significantly mediated the relationship between cervical proprioception and postural control.

Conclusions: Cervical proprioception is significantly reduced in RA patients and strongly influences postural control. Pain serves as a key mediator in this relationship, emphasizing the need for effective pain management to enhance proprioceptive and postural functions in RA patients. These findings suggest that the insights from this cross-sectional study could inform future interventions aimed at enhancing proprioception and managing pain, which may significantly benefit RA patients' postural stability and overall quality of life.