{"title":"Measurement of gas exchange surface area from DLNO and DLCO","authors":"Colin Borland","doi":"10.1016/j.resp.2025.104403","DOIUrl":null,"url":null,"abstract":"<div><div>The estimated diffusion coefficients for nitric oxide and carbon monoxide in human plasma and red cells can be inserted into the equations for Fick’s 1st and 2nd laws. The surface area of the alveolar membrane and exposed red cells can then be calculated from D<sub>LNO</sub> and D<sub>LCO</sub> (in hyperoxia). This yields a value of 18.7 m<sup>2</sup> for alveolar capillary membrane via D<sub>LNO</sub>, 19.6 m<sup>2</sup> for red cell surface area via D<sub>LCO</sub> in a seated human at rest and = 2.03m<sup>2</sup> for a membrane oxygenator. The values for a seated human are substantially less than morphometric values. This is likely due to a considerable functional reserve in the lung.</div></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":"335 ","pages":"Article 104403"},"PeriodicalIF":1.9000,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Respiratory Physiology & Neurobiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S156990482500014X","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The estimated diffusion coefficients for nitric oxide and carbon monoxide in human plasma and red cells can be inserted into the equations for Fick’s 1st and 2nd laws. The surface area of the alveolar membrane and exposed red cells can then be calculated from DLNO and DLCO (in hyperoxia). This yields a value of 18.7 m2 for alveolar capillary membrane via DLNO, 19.6 m2 for red cell surface area via DLCO in a seated human at rest and = 2.03m2 for a membrane oxygenator. The values for a seated human are substantially less than morphometric values. This is likely due to a considerable functional reserve in the lung.
期刊介绍：
Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense.
Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as:
-Mechanics of breathing-
Gas exchange and acid-base balance-
Respiration at rest and exercise-
Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen-
Embryonic and adult respiration-
Comparative respiratory physiology.
Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.
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