Risk Factors for Hemodynamic Depression After Carotid Stenting

Abstract

Background

The effects of different stents and morphology of the stenosis on hemodynamic depression (HD) and in-stent restenosis (ISR) are unclear after carotid artery stenting.

Methods

142 patients were retrospectively enrolled and stratified into straight stent and tapered stent (TS), and further stratified according to stenosis morphology to compare the differences in final events. Logistic analysis was used to determine the risk factors for the occurrence of HD.

Results

TS had a lower incidence of postprocedural HD (38.8% vs. 60.0%; P = 0.012) and 1-year ISR (1.5% vs. 8.0%; P = 0.078). In centripetal stenosis, there was no significant difference in postprocedural HD between the different stents (27.3% vs. 47.8%; P = 0.155). In contrast, for eccentric stenosis, TS was associated with a reduced risk of postprocedural HD (42.2% vs. 67.3%; P = 0.013). Logistic analyses found that eccentric stenosis (odds ratio [OR] = 2.561; 95% confidence interval [CI] = 1.100–5.965; P = 0.029), high-echo plaque (OR = 5.877; 95% CI = 1.472–23.462; P = 0.012), open-cell stent (OR = 3.173; 95% CI = 1.067–9.436; P = 0.038), and distal diameter of stent (OR = 1.541; 95% CI = 1.104–2.153; P = 0.011) were risk factors for postprocedural HD. The following factors were identified as risk factors for persistent hemodynamic depression: high-echo plaque (OR = 7.605; 95% CI = 2.105–27.468; P = 0.002) and open-cell stent (OR = 7.017; 95% CI = 1.384–35.583; P = 0.019); additionally, the further the minimum lumen distance from the carotid bifurcation, the lower the risk of persistent hemodynamic depression (OR = 0.942; 95% CI = 0.894–0.992; P = 0.024).

Conclusions

TS reduces the risk of postoperative HD and there is a trend toward a lower risk of ISR at 1 year after the procedure. Eccentric stenosis, high-echo plaque, open-cell stent, and distal diameter of stent are high-risk factors for HD.