{"title":"Digestive exophagy as a novel mechanism of amyloid-β degradation by microglial lysosomes.","authors":"Melanie Meyer-Luehmann","doi":"10.1016/j.tins.2025.01.005","DOIUrl":null,"url":null,"abstract":"<p><p>Microglia are known to be involved in the modulation of amyloid-β (Aβ) plaques in Alzheimer's disease (AD). In a recent study, Jacquet et al. describe how microglia degrade larger Aβ aggregates by forming lysosomal synapses, further implicating the microglial release of lysosomal Aβ, amongst other processes, in the growth and spread of fibrillary Aβ.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6000,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Neurosciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.tins.2025.01.005","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Microglia are known to be involved in the modulation of amyloid-β (Aβ) plaques in Alzheimer's disease (AD). In a recent study, Jacquet et al. describe how microglia degrade larger Aβ aggregates by forming lysosomal synapses, further implicating the microglial release of lysosomal Aβ, amongst other processes, in the growth and spread of fibrillary Aβ.
期刊介绍：
For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.
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