The application of contrast-enhanced ultrasound and MicroFlow Imaging in the diagnosis of breast cancer.

IF 1.9 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Journal of Medical Ultrasonics Pub Date : 2025-02-15 DOI:10.1007/s10396-025-01517-4

Ting Luo, Meizhen Chen, Hailing He, Tianan Jiang, Junjie Dong

{"title":"The application of contrast-enhanced ultrasound and MicroFlow Imaging in the diagnosis of breast cancer.","authors":"Ting Luo, Meizhen Chen, Hailing He, Tianan Jiang, Junjie Dong","doi":"10.1007/s10396-025-01517-4","DOIUrl":null,"url":null,"abstract":"Purpose: The purpose of this study was to compare the value of contrast-enhanced ultrasound (CEUS) plus MicroFlow Imaging (CEUS-MFI), MicroFlow Imaging (MFI) alone, and color Doppler flow imaging (CDFI) in the differential diagnosis of benign and malignant breast lesions.Methods: A total of 116 patients with 116 breast lesions categorized as Breast Imaging Reporting and Data System (BI-RADS) category 4 were enrolled in this prospective study. CEUS-MFI, MFI, and CDFI were used to evaluate the microvascular morphology and distribution types of breast lesions. Pathological results were considered the gold standard.Results: Compared with conventional CDFI and MFI, the CEUS-MFI technique can reveal microvasculature and distribution types at a higher resolution in breast masses. The sensitivity, specificity, and accuracy of CEUS-MFI were 96.3%, 80.6%, and 91.4%, respectively. The sensitivity, specificity, and accuracy of MFI were 87.5%, 75.0%, and 83.6%, respectively. The sensitivity, specificity, and accuracy of CDFI were 58.8%, 72.2%, and 62.9%, respectively. The accuracy was significantly different between CEUS-MFI and MFI (P = 0.024), and the accuracy was significantly different between CEUS-MFI and CDFI (P = 0.000). US BI-RADS 4A masses were downgraded based on CEUS-MFI features without any malignancy missed, with the biopsy rate decreasing from 100% (29/29) to 31.0% (9/29).Conclusion: CEUS-MFI provides improved diagnostic efficacy for breast lesions. The CEUS-MFI technique can be used as an effective supplement to conventional ultrasound in the diagnosis of breast tumors.","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Ultrasonics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10396-025-01517-4","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: The purpose of this study was to compare the value of contrast-enhanced ultrasound (CEUS) plus MicroFlow Imaging (CEUS-MFI), MicroFlow Imaging (MFI) alone, and color Doppler flow imaging (CDFI) in the differential diagnosis of benign and malignant breast lesions.

Methods: A total of 116 patients with 116 breast lesions categorized as Breast Imaging Reporting and Data System (BI-RADS) category 4 were enrolled in this prospective study. CEUS-MFI, MFI, and CDFI were used to evaluate the microvascular morphology and distribution types of breast lesions. Pathological results were considered the gold standard.

Results: Compared with conventional CDFI and MFI, the CEUS-MFI technique can reveal microvasculature and distribution types at a higher resolution in breast masses. The sensitivity, specificity, and accuracy of CEUS-MFI were 96.3%, 80.6%, and 91.4%, respectively. The sensitivity, specificity, and accuracy of MFI were 87.5%, 75.0%, and 83.6%, respectively. The sensitivity, specificity, and accuracy of CDFI were 58.8%, 72.2%, and 62.9%, respectively. The accuracy was significantly different between CEUS-MFI and MFI (P = 0.024), and the accuracy was significantly different between CEUS-MFI and CDFI (P = 0.000). US BI-RADS 4A masses were downgraded based on CEUS-MFI features without any malignancy missed, with the biopsy rate decreasing from 100% (29/29) to 31.0% (9/29).

Conclusion: CEUS-MFI provides improved diagnostic efficacy for breast lesions. The CEUS-MFI technique can be used as an effective supplement to conventional ultrasound in the diagnosis of breast tumors.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

目的：本研究旨在比较对比增强超声（CEUS）加微血流成像（CEUS-MFI）、单独微血流成像（MFI）和彩色多普勒血流成像（CDFI）在乳腺良恶性病变鉴别诊断中的价值：这项前瞻性研究共纳入了 116 名乳腺病变患者，这些患者的乳腺病变被归类为乳腺影像报告和数据系统（BI-RADS）第 4 类。CEUS-MFI、MFI和CDFI用于评估乳腺病变的微血管形态和分布类型。病理结果被视为金标准：结果：与传统的 CDFI 和 MFI 相比，CEUS-MFI 技术能以更高的分辨率显示乳腺肿块的微血管形态和分布类型。CEUS-MFI的敏感性、特异性和准确性分别为96.3%、80.6%和91.4%。MFI的敏感性、特异性和准确性分别为87.5%、75.0%和83.6%。CDFI的敏感性、特异性和准确性分别为58.8%、72.2%和62.9%。CEUS-MFI和MFI的准确性有明显差异（P = 0.024），CEUS-MFI和CDFI的准确性有明显差异（P = 0.000）。根据CEUS-MFI特征对美国BI-RADS 4A肿块进行降级，未漏诊任何恶性肿瘤，活检率从100%（29/29）降至31.0%（9/29）：结论：CEUS-MFI提高了乳腺病变的诊断效率。结论：CEUS-MFI 提高了乳腺病变的诊断效率，可作为传统超声诊断乳腺肿瘤的有效补充。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Journal of Medical Ultrasonics 医学-核医学

CiteScore

3.30

自引率

11.10%

发文量

102

审稿时长

>12 weeks

期刊介绍： The Journal of Medical Ultrasonics is the official journal of the Japan Society of Ultrasonics in Medicine. The main purpose of the journal is to provide forum for the publication of papers documenting recent advances and new developments in the entire field of ultrasound in medicine and biology, encompassing both the medical and the engineering aspects of the science.The journal welcomes original articles, review articles, images, and letters to the editor.The journal also provides state-of-the-art information such as announcements from the boards and the committees of the society.