Alignment of counseling around topical steroids will improve morbidity associated with lichen sclerosus

JAPhA Pharmacotherapy Pub Date : 2024-12-01 Epub Date: 2025-01-11 DOI:10.1016/j.japhar.2025.100010
Margaret E. Greer, Paras P. Vakharia, Melissa M. Mauskar
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Abstract

Ultrapotent topical steroids are the first-line treatment for lichen sclerosus, a chronic inflammatory disease that most commonly affects the genital and anal regions. Lichen sclerosus can cause profound morbidity and can progress to squamous cell carcinoma. Therefore, treatment is essential to mitigate these complications. Despite the accessibility, relative affordability, and safety profiles of topical steroids, many clinicians, pharmacists, and patients are hesitant to use them. This paper outlines the importance of chronic steroid use for managing lichen sclerosus to prevent disease sequelae and aims to educate readers on ways physicians and pharmacists can mitigate steroid phobia.
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围绕局部类固醇的咨询将改善与硬化地衣相关的发病率
超高效外用类固醇是硬化地衣的一线治疗方法,硬化地衣是一种最常影响生殖器和肛门区域的慢性炎症性疾病。硬化性地衣可引起严重的发病率,并可发展为鳞状细胞癌。因此,治疗对于减轻这些并发症至关重要。尽管外用类固醇具有可及性、相对可负担性和安全性,但许多临床医生、药剂师和患者对使用它们犹豫不决。本文概述了慢性类固醇使用对管理硬化地衣预防疾病后遗症的重要性,旨在教育医生和药剂师如何减轻类固醇恐惧症的读者。
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