{"title":"DNA and gold(III) complexes with nitrogen-containing ligands","authors":"Igor V. Mironov, Viktoria Yu Kharlamova","doi":"10.1016/j.ica.2025.122591","DOIUrl":null,"url":null,"abstract":"<div><div>The interaction of four gold(III) complexes with N-containing polydentate ligands – Au (bipy)(OH)<sub>2</sub><sup>+</sup>, Au(phen)(OH)<sub>2</sub><sup>+</sup>, Au(C<sub>9</sub>H<sub>19</sub>N<sub>4</sub>)<sup>2+</sup>, Au(C<sub>14</sub>H<sub>22</sub>N<sub>4</sub>)<sup>+</sup> and one gold(I) complex Au(GSH)<sub>2</sub><sup>3−</sup> – with salmon sperm DNA in an aqueous solution at 25 °C, pH 7.4, 0.1 M NaCl was studied. In the UV spectra of the complexes in the presence of DNA, no changes were observed compared to the spectra of solutions without DNA, indicating the absence of formation of new chemical bonds. In the fluorescence spectra of solutions containing DNA and ethidium bromide, a noticeable decrease in intensity was observed only for the macrocyclic unsaturated complex Au(C<sub>14</sub>H<sub>22</sub>N<sub>4</sub>)<sup>+</sup>. For other complexes, the changes were insignificant, i.e., they do not intercalate into DNA. It was also shown that the presence of DNA does not affect the redox interaction with glutathione of the studied gold(III) complexes.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"580 ","pages":"Article 122591"},"PeriodicalIF":2.7000,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inorganica Chimica Acta","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S002016932500057X","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
The interaction of four gold(III) complexes with N-containing polydentate ligands – Au (bipy)(OH)2+, Au(phen)(OH)2+, Au(C9H19N4)2+, Au(C14H22N4)+ and one gold(I) complex Au(GSH)23− – with salmon sperm DNA in an aqueous solution at 25 °C, pH 7.4, 0.1 M NaCl was studied. In the UV spectra of the complexes in the presence of DNA, no changes were observed compared to the spectra of solutions without DNA, indicating the absence of formation of new chemical bonds. In the fluorescence spectra of solutions containing DNA and ethidium bromide, a noticeable decrease in intensity was observed only for the macrocyclic unsaturated complex Au(C14H22N4)+. For other complexes, the changes were insignificant, i.e., they do not intercalate into DNA. It was also shown that the presence of DNA does not affect the redox interaction with glutathione of the studied gold(III) complexes.
期刊介绍：
Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews.
Topics covered include:
• chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies;
• synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs);
• reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models;
• applications of inorganic compounds, metallodrugs and molecule-based materials.
Papers composed primarily of structural reports will typically not be considered for publication.
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