DNA and gold(III) complexes with nitrogen-containing ligands

IF 3.2 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Inorganica Chimica Acta Pub Date : 2025-02-11 DOI:10.1016/j.ica.2025.122591

Igor V. Mironov, Viktoria Yu Kharlamova

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Abstract

The interaction of four gold(III) complexes with N-containing polydentate ligands – Au (bipy)(OH)₂⁺, Au(phen)(OH)₂⁺, Au(C₉H₁₉N₄)²⁺, Au(C₁₄H₂₂N₄)⁺ and one gold(I) complex Au(GSH)₂³⁻ – with salmon sperm DNA in an aqueous solution at 25 °C, pH 7.4, 0.1 M NaCl was studied. In the UV spectra of the complexes in the presence of DNA, no changes were observed compared to the spectra of solutions without DNA, indicating the absence of formation of new chemical bonds. In the fluorescence spectra of solutions containing DNA and ethidium bromide, a noticeable decrease in intensity was observed only for the macrocyclic unsaturated complex Au(C₁₄H₂₂N₄)⁺. For other complexes, the changes were insignificant, i.e., they do not intercalate into DNA. It was also shown that the presence of DNA does not affect the redox interaction with glutathione of the studied gold(III) complexes.

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含氮配体的DNA和金（III）配合物

研究了金（III）配合物Au(bipy)(OH)2+、Au(phen)(OH)2+、Au(C9H19N4)2+、Au(C14H22N4)+和金(I)配合物Au(GSH)23−-在25℃、pH 7.4、0.1 M NaCl条件下与鲑鱼精子DNA的相互作用。在有DNA存在的复合物的紫外光谱中，与没有DNA的溶液的光谱相比，没有观察到任何变化，这表明没有形成新的化学键。在含有DNA和溴化乙啶溶液的荧光光谱中，只有大环不饱和配合物Au(C14H22N4)+的荧光强度明显降低。对于其他复合物，这些变化是微不足道的，也就是说，它们不会嵌入DNA。研究还表明，DNA的存在不影响所研究的金（III）配合物与谷胱甘肽的氧化还原相互作用。

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来源期刊

Inorganica Chimica Acta 化学-无机化学与核化学

CiteScore

6.00

自引率

3.60%

发文量

440

审稿时长

35 days

期刊介绍： Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews. Topics covered include: • chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies; • synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs); • reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models; • applications of inorganic compounds, metallodrugs and molecule-based materials. Papers composed primarily of structural reports will typically not be considered for publication.