Studying the Effect of AgNPs Derived from Ag-Complex on Peroxidase Enzymes in Patients with Type2 Diabetes Caused by White Rabbits

Abstract

The state of oxidative stress concomitant with type 2 diabetes mellitus (DM) is recognized as a significant factor leading to impaired glycemic control. This study is designed to elucidate the clinical benefits of employing silver and palladium nanocompounds in addressing oxidative disturbances. The investigation encompasses twenty rabbits aged between 6 to 12 months, divided into four groups, each comprising five rabbits. The first group comprises healthy rabbits, serving as the control group. The second group consists of induced diabetic rabbits left untreated, also serving as a control group. The third and fourth groups encompass induced diabetic rabbits treated with silver nanocompounds at concentrations of 10 000 micrograms/mL and 20 000 µg mL⁻¹, respectively, relative to body weight. A singular daily dose is administered for a duration of two weeks. The study's findings demonstrated the effects of silver nanocompounds in mitigating oxidative disturbances by reducing blood glucose levels and lowering anti-thyroid peroxidase antibodies (anti-TPO), glutathione peroxidase (GSH-Px), and catalase (CAT) levels. These effects are dose-dependent and significantly associated with an observable enhancement in glycemic control.