{"title":"Front Cover: HPPE Activates NRF2 Signaling by Liberating Heavy Metal Stores (ChemBioChem 4/2025)","authors":"Rebecca Freeman, Michael J. Bollong","doi":"10.1002/cbic.202580401","DOIUrl":null,"url":null,"abstract":"<p>Small molecule ionophore, HPPE, is depicted as a magnet, acting to liberate cellular stores of Zn<sup>2+</sup> and Cu<sup>2+</sup>. Increased levels of labile metal pools result in nonlethal of oxidative stress in cells, sensed by NRF2 repressor protein and oxidative stress sensor, KEAP1. Consequently, NRF2 is stabilized, resulting in the transcriptional activation of cytoprotective genes, illustrated as a shield with a medical cross. More details can be found in the article 10.1002/cbic.202400529 by Rebecca Freeman and Michael J. Bollong.<figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure>\n </p>","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":"26 4","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cbic.202580401","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemBioChem","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cbic.202580401","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
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Abstract
Small molecule ionophore, HPPE, is depicted as a magnet, acting to liberate cellular stores of Zn2+ and Cu2+. Increased levels of labile metal pools result in nonlethal of oxidative stress in cells, sensed by NRF2 repressor protein and oxidative stress sensor, KEAP1. Consequently, NRF2 is stabilized, resulting in the transcriptional activation of cytoprotective genes, illustrated as a shield with a medical cross. More details can be found in the article 10.1002/cbic.202400529 by Rebecca Freeman and Michael J. Bollong.
期刊介绍：
ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).
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